Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.62 |
| ▸ | NPC1 | O15118 | 2/20 | 0.62 |
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | CNR2 | P34972 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | PLAU | P00749 | 1/20 | 0.56 |
| ▸ | ELANE | P08246 | 1/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.54 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.54 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4917828 | 0.86 | RAB9A (0.68) | ALDH1A1NPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL8691052 | 0.80 | MAPT (0.76) | ALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL22283905 | 0.79 | SMN1; SMN2 (0.61) | ALDH1A1NPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL4928502 | 0.77 | HTT (0.73) | ALDH1A1NPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL28497417 | 0.77 | NPC1 (1.00) | ALDH1A1NPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL5862101 | 0.77 | NPC1 (1.00) | ALDH1A1NPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL8938110 | 0.76 | HDAC8 (0.53) | ALDH1A1RAB9AMAPTSMN1; SMN2CNR2 | |
| SCHEMBL4032340 | 0.75 | NPC1 (0.66) | ALDH1A1NPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL6938387 | 0.75 | NPC1 (0.55) | ALDH1A1NPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL6171613 | 0.75 | RAB9A (1.00) | ALDH1A1NPC1RAB9AMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1771410-A1 | SPIROLACTAMS AND THEIR SYNTHESIS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2007-04-11 | — | — | EP | disclosed |
| WO-2005108356-A1 | SPIROLACTAMS AND THEIR SYNTHESIS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2005-11-17 | — | — | WO | disclosed |