SCHEMBL5169593

SCHEMBL5169593

CN(CC(=O)c1ccc2ccccc2c1)Cc1ccc(C(C)(C)C)cc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE P22303 4/20 0.57
SIGMAR1 Q99720 4/20 0.48
TMEM97 Q5BJF2 3/20 0.48
NR1I2 O75469 1/20 0.48
LMNA P02545 1/20 0.48
ADRA2A P08913 1/20 0.48
CYP2D6 P10635 1/20 0.48
SLC6A2 P23975 1/20 0.48
HTR2A P28223 1/20 0.48
SLC6A4 P31645 1/20 0.48
KCNH2 Q12809 1/20 0.48
OPRM1 P35372 2/20 0.47
SMN1; SMN2 Q16637 2/20 0.45
KDM4E B2RXH2 1/20 0.45
HPGD P15428 1/20 0.45
PTPN1 P18031 1/20 0.44
RAB9A P51151 2/20 0.43
NPC1 O15118 1/20 0.43
ALDH1A1 P00352 1/20 0.43
NR1H4 Q96RI1 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5166494 0.93 ACHE (0.51) ACHESIGMAR1TMEM97NR1I2LMNA
SCHEMBL5166698 0.85 SIGMAR1 (0.51) ACHESIGMAR1TMEM97NR1I2LMNA
SCHEMBL5167798 0.85 ACHE (0.51) ACHESIGMAR1TMEM97NR1I2LMNA
SCHEMBL5170362 0.84 SIGMAR1 (0.54) ACHESIGMAR1TMEM97NR1I2LMNA
Hydrochloric Acid SCHEMBL5166526 0.83 SIGMAR1 (0.53) ACHESIGMAR1TMEM97NR1I2LMNA
SCHEMBL5169424 0.82 LMNA (0.46) ACHESIGMAR1TMEM97NR1I2LMNA
SCHEMBL5167511 0.81 PPARG (0.49) ACHESIGMAR1TMEM97LMNASLC6A2
SCHEMBL5169709 0.81 ESRRG (0.44) ACHESIGMAR1TMEM97NR1H4MEN1
SCHEMBL5169846 0.81 KCNK3 (0.48) ACHESIGMAR1TMEM97NR1I2LMNA
SCHEMBL5165994 0.81 TP53 (0.52) ACHESIGMAR1LMNASMN1; SMN2RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1561744-A2 AMINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND THEIR USE AS ANTIMYCOTIC AGENT POLA CHEMICAL INDUSTRIES INC. (JP) 2005-08-10 EP claimed
US-6329399-B1 Antifungal amine derivatives and processing for producing the same POLA CHEMICAL INDUSTRIES, INC. (JP) 2001-12-11 US claimed
EP-1020426-A1 AMINE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME POLA CHEMICAL INDUSTRIES, INC. (JP) 2000-07-19 EP claimed
EP-1561744-B1 AMINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND THEIR USE AS ANTIMYCOTIC AGENT POLA CHEM IND INC (JP) 2007-04-18 EP disclosed
EP-1561744-A2 AMINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND THEIR USE AS ANTIMYCOTIC AGENT POLA CHEMICAL INDUSTRIES INC. (JP) 2005-08-10 EP disclosed
US-6329399-B1 Antifungal amine derivatives and processing for producing the same POLA CHEMICAL INDUSTRIES, INC. (JP) 2001-12-11 US disclosed
EP-1020426-A1 AMINE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME POLA CHEMICAL INDUSTRIES, INC. (JP) 2000-07-19 EP disclosed