Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | CES2 | O00748 | 3/20 | 0.41 |
| ▸ | CES1 | P23141 | 3/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.37 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.36 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
| ▸ | PPARA | Q07869 | 2/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7313573 | 0.89 | CES2 (0.41) | NOTUMCES2CES1EPHX2SCN8A | |
| SCHEMBL3873475 | 0.85 | CES2 (0.38) | NOTUMCES2CES1EPHX2SCN8A | |
| SCHEMBL17186806 | 0.81 | PPARA (0.47) | CES2CES1ALDH1A1LMNAPPARA | |
| SCHEMBL23519094 | 0.77 | PPARA (0.51) | NOTUMEPHX2SCN8ASCN10APPARA | |
| SCHEMBL29795192 | 0.76 | EPHX2 (0.46) | NOTUMCES2CES1EPHX2SCN8A | |
| SCHEMBL17186832 | 0.76 | EPHX2 (0.46) | NOTUMCES2CES1EPHX2SCN8A | |
| SCHEMBL23519089 | 0.74 | CXCL8 (0.46) | NOTUMCES2CES1EPHX2ALDH1A1 | |
| SCHEMBL3827377 | 0.74 | CES2 (0.45) | CES2CES1EPHX2SCN8ASCN10A | |
| SCHEMBL15737124 | 0.73 | CES2 (0.32) | CES2CES1EPHX2FFAR1 | |
| SCHEMBL10180776 | 0.73 | CES2 (0.41) | CES2CES1EPHX2SCN8ASCN10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685146-B1 | CRYSTALLINE COMPOUND OF 4'-DEMETHYL-4'-PHOSPHATE-2\",3\"-BISPENTAFLUOROPHENOXYACETYL-4\",6\"-ETHYLIDENE-ß-D-EPIPODOPHYLLOTOXIN GLUCOSIDE EITHER IN ITS FREE FORM OR SOLVATED WITH ETHANOL | PF MEDICAMENT (FR) | 2007-04-25 | — | — | EP | disclosed |
| US-20070042971-A1 | Crystalline compound of 4'-demethyl-4'-phosphate-2\", 3\"-bispentafluorophenoxy-acetyl-4\", 6\"-ethylidene-beta-d-epipodophyllotoxin glucoside either in its free form or solvated with ethanol | PIERRE FABRE MEDICAMENT (FR) | 2007-02-22 | — | — | US | disclosed |
| EP-1685146-A1 | CRYSTALLINE COMPOUND OF 4'-DEMETHYL-4'-PHOSPHATE-2\",3\"-BISPENTAFLUOROPHENOXYACETYL-4\",6\"-ETHYLIDENE-ß-D-EPIPODOPHYLLOTOXIN GLUCOSIDE EITHER IN ITS FREE FORM OR SOLVATED WITH ETHANOL | PIERRE FABRE MEDICAMENT (FR) | 2006-08-02 | — | — | EP | disclosed |
| WO-2005028492-A1 | CRYSTALLINE COMPOUND OF 4'-DEMETHYL-4'-PHOSPHATE-2',3'-BISPENTAFLUOROPHENOXYACETYL-4',6'-ETHYLIDENE-β-D-EPIPODOPHYLLOTOXIN GLUCOSIDE EITHER IN ITS FREE FORM OR SOLVATED WITH ETHANOL | PIERRE FABRE MEDICAMENT (FR) | 2005-03-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070042971-A1 | Crystalline compound of 4'-demethyl-4'-phosphate-2\", 3\"-bispentafluorophenoxy-acetyl-4\", 6\"-ethylidene-beta-d-epipodophyllotoxin glucoside either in its free form or solvated with ethanol | PPP4C, PYGB, PYGL | NOTUM 1197/4885CES2 1181/4885CES1 2213/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.