Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.37 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.35 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5194058 | 0.91 | HRH3 (0.41) | CHRNB2CHRNA7CHRNA4GRM5GABRA5 | |
| SCHEMBL5171940 | 0.88 | CYP4F2 (0.35) | CYP4F2CYP4A11GRIN1GRIN2BPOLB | |
| SCHEMBL5713478 | 0.86 | HRH3 (0.45) | — | |
| SCHEMBL5170957 | 0.85 | CHRNB2 (0.38) | CHRNB2CHRNA7CHRNA4GRM5GABRA5 | |
| SCHEMBL5672109 | 0.82 | HPGDS (0.36) | GABRA5 | |
| SCHEMBL5171933 | 0.82 | HRH3 (0.41) | GRM5CYP4F2CYP4A11GRIN1GRIN2B | |
| SCHEMBL5172012 | 0.80 | HRH3 (0.40) | CYP4F2CYP4A11GRIN1GRIN2B | |
| SCHEMBL5184064 | 0.80 | GRIN1 (0.33) | CYP4F2CYP4A11GRIN1GRIN2B | |
| SCHEMBL5170762 | 0.78 | SMO (0.33) | CYP4F2CYP4A11POLB | |
| SCHEMBL5664186 | 0.78 | GPR119 (0.49) | GABRA5CYP4F2CYP4A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778643-A1 | TETRAHYDROBENZAZEPINES AS ANTAGONISTS AND/OR REVERSE AGONISTS OF THE HISTAMINE H3 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006018260-A1 | TETRAHYDROBENZAZEPINES AS ANTAGONISTS AND/OR REVERSE AGONISTS OF THE HISTAMINE H 3 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2006-02-23 | — | — | WO | disclosed |