Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 2/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.33 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.33 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 5/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | CSF1R | P07333 | 1/20 | 0.31 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5172012 | 0.87 | HRH3 (0.40) | GRIN1GRIN2BCYP4F2CYP4A11GPR119 | |
| SCHEMBL5184067 | 0.85 | GRIN1 (0.34) | GRIN1GRIN2BGABRA1TDP1ENPP2 | |
| SCHEMBL5170953 | 0.80 | CHRNB2 (0.39) | GRIN1GRIN2BCYP4F2CYP4A11 | |
| SCHEMBL5171940 | 0.80 | CYP4F2 (0.35) | GRIN1GRIN2BCYP4F2CYP4A11ALDH1A1 | |
| SCHEMBL5663494 | 0.78 | GPR119 (0.47) | CYP4F2CYP4A11GPR119HPGDSMN1; SMN2 | |
| SCHEMBL5171933 | 0.77 | HRH3 (0.41) | GRIN1GRIN2BCYP4F2CYP4A11GABRA1 | |
| SCHEMBL5194058 | 0.77 | HRH3 (0.41) | — | |
| SCHEMBL5170173 | 0.75 | ALDH1A1 (0.34) | GRIN1GRIN2BCYP4F2CYP4A11ALDH1A1 | |
| SCHEMBL5170912 | 0.74 | GRIN1 (0.35) | GRIN1GRIN2BCYP4F2CYP4A11ALDH1A1 | |
| SCHEMBL5170182 | 0.74 | HCRTR1 (0.32) | GRIN1GRIN2BLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778643-A1 | TETRAHYDROBENZAZEPINES AS ANTAGONISTS AND/OR REVERSE AGONISTS OF THE HISTAMINE H3 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006018260-A1 | TETRAHYDROBENZAZEPINES AS ANTAGONISTS AND/OR REVERSE AGONISTS OF THE HISTAMINE H 3 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2006-02-23 | — | — | WO | disclosed |