Sugi Predict

Sugi Predict / Compounds / SCHEMBL517515

SCHEMBL517515

SCHEMBL517515

CC(C)(C)OC(=O)N1CCC(NCc2ccccc2)C(F)C1

nearest known ligand 0.53

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ USP30 Q70CQ3 4/20 0.53
▸ GPR119 Q8TDV5 4/20 0.51
▸ STS P08842 1/20 0.51
▸ JAK2 O60674 1/20 0.51
▸ JAK1 P23458 1/20 0.51
▸ TACR1 P25103 1/20 0.48
▸ KEAP1 Q14145 1/20 0.48
▸ NFE2L2 Q16236 1/20 0.48
▸ KDM4E B2RXH2 1/20 0.48
▸ PKM P14618 1/20 0.48
▸ LMNA P02545 1/20 0.48
▸ TP53 P04637 1/20 0.47
▸ ACHE P22303 1/20 0.45
▸ TDP1 Q9NUW8 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2292403 1.00 USP30 (0.53) USP30GPR119STSJAK2JAK1
SCHEMBL26077407 1.00 USP30 (0.53) USP30GPR119STSJAK2JAK1
SCHEMBL517516 1.00 USP30 (0.53) USP30GPR119STSJAK2JAK1
SCHEMBL2273817 1.00 USP30 (0.53) USP30GPR119STSJAK2JAK1
SCHEMBL5768083 1.00 USP30 (0.53) USP30GPR119STSJAK2JAK1
SCHEMBL2292408 1.00 USP30 (0.53) USP30GPR119STSJAK2JAK1
SCHEMBL20766014 0.90 DNMT3A (0.46) USP30GPR119TACR1TP53
SCHEMBL29673228 0.90 DNMT3A (0.46) USP30GPR119TACR1TP53
SCHEMBL20778648 0.90 DNMT3A (0.46) USP30GPR119TACR1TP53
SCHEMBL20794795 0.90 DNMT3A (0.46) USP30GPR119TACR1TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 125 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250049772-A1 PIPERIDINYL-3-(ARYLOXY)PROPANAMIDES AND PROPANOATES TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2025-02-13 — — US disclosed
US-12005054-B2 Piperidinyl-3-(aryloxy)propanamides and propanoates TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2024-06-11 — — US disclosed
CN-112384509-B Furin inhibitors 葛兰素史密斯克莱知识产权发展有限公司 2024-04-30 — — CN disclosed
CN-112236423-B Piperidinyl-3- (aryloxy) propanamides and propionic acid esters 武田药品工业株式会社 2024-02-06 — — CN disclosed
EP-3790871-B1 FURIN INHIBITORS GLAXOSMITHKLINE IP DEV LTD (GB) 2024-01-24 — — EP disclosed
US-11773078-B2 Furin inhibitors GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2023-10-03 — — US disclosed
US-11773078-B2 Furin inhibitors GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2023-10-03 — — US disclosed
US-20230021834-A1 PIPERIDINYL-3-(ARYLOXY)PROPANAMIDES AND PROPANOATES TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2023-01-26 — — US disclosed
US-20230021834-A1 PIPERIDINYL-3-(ARYLOXY)PROPANAMIDES AND PROPANOATES TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2023-01-26 — — US disclosed
US-20220315556-A1 FURIN INHIBITORS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2022-10-06 — — US disclosed
EP-1583537-A3 PIPERIDINE COMPOUNDS AS ANTIBACTERIALS GLAXO GROUP LIMITED (GB) 2005-12-14 — — EP disclosed
EP-1583537-A2 PIPERIDINE COMPOUNDS AS ANTIBACTERIALS GLAXO GROUP LIMITED (GB) 2005-10-12 — — EP disclosed
EP-1578743-A2 ANTIBACTERIAL AGENTS GLAXO GROUP LIMITED (GB) 2005-09-28 — — EP disclosed
US-20050159411-A1 Aminopiperidine derivatives GLAXO GROUP LIMITED (GB) 2005-07-21 — — US disclosed
US-20050085494-A1 Aminopiperidine compounds, process for their preparation, and pharmaceutical compositions containing them GLAXO GROUP LIMITED (GB) 2005-04-21 — — US disclosed
EP-1470125-A1 AMINOPIPERIDINE DERIVATIVES GLAXO GROUP LIMITED (GB) 2004-10-27 — — EP disclosed
WO-2004058144-A2 ANTIBACTERIAL AGENTS GLAXO GROUP LIMITED (GB) 2004-07-15 — — WO disclosed
WO-2004002490-A2 PIPERIDINE COMPOUNDS AS ANTIBACTERIALS GLAXO GROUP LIMITED (GB) 2004-01-08 — — WO disclosed
WO-2003064421-A1 AMINOPIPERIDINE DERIVATIVES GLAXO GROUP LIMITED (GB) 2003-08-07 — — WO disclosed
US-5837715-A 3-fluoro-4-aminopiperidine derivatives as 5-HT receptor agonists MERCK SHARP & DOHME LTD. (GB) 1998-11-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220315556-A1 FURIN INHIBITORS FURIN, TGFB1, PCSK7 USP30 2077/4885GPR119 2318/4885STS 1739/4885
US-12005054-B2 Piperidinyl-3-(aryloxy)propanamides and propanoates SSTR4, SSTR3, NPY4R USP30 1713/4885GPR119 31/4885STS 372/4885
US-20250049772-A1 PIPERIDINYL-3-(ARYLOXY)PROPANAMIDES AND PROPANOATES SSTR4, SSTR3, NPY4R USP30 1713/4885GPR119 31/4885STS 372/4885
US-20050085494-A1 Aminopiperidine compounds, process for their preparation, and pharmaceutical compositions containing them NPEPPS, AASDHPPT, DNPEP USP30 3815/4885GPR119 541/4885STS 4412/4885
US-11773078-B2 Furin inhibitors FURIN, TGFB1, PCSK7 USP30 2077/4885GPR119 2318/4885STS 1739/4885
US-20230021834-A1 PIPERIDINYL-3-(ARYLOXY)PROPANAMIDES AND PROPANOATES SSTR4, SSTR3, NPY4R USP30 1713/4885GPR119 31/4885STS 372/4885
US-20050159411-A1 Aminopiperidine derivatives AMPD2, AMPD3, NPEPPS USP30 3209/4885GPR119 2446/4885STS 4352/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.