Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 6/20 | 0.36 |
| ▸ | GRM3 | Q14832 | 6/20 | 0.36 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CASP6 | P55212 | 1/20 | 0.34 |
| ▸ | TERT | O14746 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5175389 | 0.76 | PIM1 (0.35) | PIM1GRM2GRM3SLC9A1ALDH1A1 | |
| SCHEMBL8772911 | 0.71 | MAPT (0.40) | PIM1GRM2GRM3ALDH1A1HSD17B10 | |
| SCHEMBL595607 | 0.69 | ALDH1A1 (0.34) | PIM1GRM2GRM3ALDH1A1HDAC1 | |
| SCHEMBL28728918 | 0.68 | ACHE (0.36) | PIM1GRM2GRM3 | |
| SCHEMBL15231536 | 0.67 | CES2 (0.42) | — | |
| SCHEMBL16555709 | 0.67 | LMNA (0.39) | PIM1ALDH1A1 | |
| SCHEMBL900729 | 0.67 | SMN1; SMN2 (0.49) | PIM1ALDH1A1 | |
| SCHEMBL13751211 | 0.67 | PIM1 (0.34) | PIM1GRM2GRM3SLC9A1ALDH1A1 | |
| SCHEMBL4355959 | 0.66 | SMN1; SMN2 (0.53) | PIM1POLBALDH1A1HDAC1HDAC6 | |
| SCHEMBL9475992 | 0.65 | MAPT (0.37) | PIM1GRM2GRM3CASP6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1867636-A1 | PYRIDYLMETHYLSULFONE DERIVATIVE | Daiichi Sankyo Company, Limited (JP) | 2007-12-19 | — | — | EP | disclosed |