SCHEMBL51755

SCHEMBL51755

COC(=O)c1ccc(Cl)c([N+](=O)[O-])c1

nearest known ligand 0.72

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.72
VCAM1 P19320 3/20 0.68
MAPT P10636 3/20 0.65
ALDH1A1 P00352 3/20 0.65
RAF1 P04049 1/20 0.65
HPGD P15428 1/20 0.65
MAPK1 P28482 1/20 0.65
GFER P55789 1/20 0.65
PAX8 Q06710 1/20 0.65
HTT P42858 1/20 0.57
POLB P06746 1/20 0.56
KMT2A Q03164 2/20 0.55
KDM4E B2RXH2 1/20 0.55
MEN1 O00255 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11137980 0.87 ALDH1A1 (0.61) LMNAVCAM1MAPTALDH1A1RAF1
SCHEMBL12138057 0.86 LMNA (0.56) LMNAVCAM1MAPTALDH1A1RAF1
SCHEMBL27770136 0.85 VCAM1 (0.70) LMNAVCAM1MAPTALDH1A1RAF1
SCHEMBL10328475 0.85 VCAM1 (0.70) LMNAVCAM1MAPTALDH1A1RAF1
SCHEMBL5734347 0.85 VCAM1 (0.68) LMNAVCAM1MAPTALDH1A1HPGD
SCHEMBL1467163 0.83 HTT (0.73) LMNAVCAM1MAPTALDH1A1RAF1
SCHEMBL30863327 0.83 VCAM1 (0.66) LMNAVCAM1MAPTALDH1A1HPGD
SCHEMBL1761873 0.83 VCAM1 (0.62) LMNAVCAM1MAPTALDH1A1RAF1
SCHEMBL260606 0.83 KMT2A (0.64) LMNAVCAM1MAPTALDH1A1RAF1
SCHEMBL1028629 0.83 VCAM1 (0.62) LMNAVCAM1MAPTALDH1A1RAF1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 479 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116332779-B Preparation method of 3, 4-diaminomethyl benzoate 苏州敬业医药化工有限公司 2025-06-10 CN claimed
CN-116332779-A Preparation method of 3, 4-diaminomethyl benzoate 苏州敬业医药化工有限公司 2023-06-27 CN claimed
EP-3745105-B1 TEMPERATURE DETECTION LABEL AND ARTICLE MANAGEMENT DEVICE USING SAME HITACHI LTD (JP) 2025-08-27 EP disclosed
CN-116120239-B Aromatic six-membered cycloimidazole derivative, and preparation method and application thereof 沈阳药科大学 2025-06-24 CN disclosed
US-20250197396-A1 COMPOUNDS FOR INHIBITING INOSITOL HEXAKISPHOSPHATE KINASE (IP6K) AND METHODS OF USE THEREOF LIEBER INSTITUTE, INC. 2025-06-19 US disclosed
CN-116332779-B Preparation method of 3, 4-diaminomethyl benzoate 苏州敬业医药化工有限公司 2025-06-10 CN disclosed
CN-116332779-B Preparation method of 3, 4-diaminomethyl benzoate 苏州敬业医药化工有限公司 2025-06-10 CN disclosed
US-20250179008-A1 ANTIBACTERIAL AGENTS TAXIS PHARMACEUTICALS, INC. (US) 2025-06-05 US disclosed
US-20250163038-A1 CBL-B MODULATORS AND USES THEREOF NIMBUS CLIO, INC. 2025-05-22 US disclosed
CN-119100992-A Preparation method of tergolian intermediate and derivative thereof 帕潘纳(北京)科技有限公司 2024-12-10 CN disclosed
US-20240400247-A1 TEMPERATURE INDICATOR MANUFACTURING SYSTEM AND TEMPERATURE INDICATOR MANUFACTURING METHOD HITACHI INDUSTRIAL EQUIPMENT SYSTEMS CO., LTD. (JP) 2024-12-05 US disclosed
EP-0574494-A1 INDOLES USEFUL AS PLATELET ACTIVATING FACTOR ANTAGONISTS ABBOTT LABORATORIES (US) 1993-12-22 EP disclosed
US-5159114-A Anticholesterol agents RHONE-POULENC SANTE (FR) 1992-10-27 US disclosed
WO-1992014732-A1 INDOLES USEFUL AS PLATELET ACTIVATING FACTOR ANTAGONISTS ABBOTT LABORATORIES (US) 1992-09-03 WO disclosed
EP-0499987-A1 Platelet activating factor antagonists ABBOTT LABORATORIES (US) 1992-08-26 EP disclosed
US-5091394-A BENZOYLGUANIDINES, A PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND MEDICAMENTS CONTAINING THEM HOECHST AKTIENGESELLSCHAFT (DE) 1992-02-25 US disclosed
EP-0424194-A2 Benzanilide derivatives and their use as anti-atherosclerotic agents RHONE-POULENC SANTE (FR) 1991-04-24 EP disclosed
CN-1050018-A Benzoylguanidines, they the preparation method, they are as the application of medicament and the medicament that contains them HOECHST AG (DE) 1991-03-20 CN disclosed
US-4916149-A Diuretic and saluretic 4-chloro-3-sulfamoylbenzoic acid hydrazides CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT. (HU) 1990-04-10 US disclosed
US-4145342-A NITRO-DIPHENYLAMINO-AZO-PHENYL DYESTUFFS CONTAINING A POLYALKYENEOXY GROUP BAYER AKTIENGESELLSCHAFT (DE) 1979-03-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250163038-A1 CBL-B MODULATORS AND USES THEREOF CBLB, CBL, CBLC LMNA 1642/4885VCAM1 3051/4885MAPT 4064/4885
US-20250197396-A1 COMPOUNDS FOR INHIBITING INOSITOL HEXAKISPHOSPHATE KINASE (IP6K) AND METHODS OF USE THEREOF IP6K1, IP6K2, IP6K3 LMNA 3930/4885VCAM1 4338/4885MAPT 4318/4885
US-20250179008-A1 ANTIBACTERIAL AGENTS ALK, ROS1, NOX1 LMNA 1817/4885VCAM1 3465/4885MAPT 4784/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.