Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.73 |
| ▸ | RAB9A | P51151 | 2/20 | 0.73 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.69 |
| ▸ | LTA4H | P09960 | 3/20 | 0.68 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.58 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | FAAH | O00519 | 1/20 | 0.54 |
| ▸ | BCHE | P06276 | 1/20 | 0.54 |
| ▸ | ACHE | P22303 | 1/20 | 0.54 |
| ▸ | DRD2 | P14416 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | HTR2C | P28335 | 1/20 | 0.54 |
| ▸ | HTR2B | P41595 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5175861 | 0.94 | NPC1 (0.75) | NPC1RAB9AHRH3LTA4HS1PR5 | |
| SCHEMBL5173905 | 0.91 | S1PR5 (0.71) | NPC1RAB9AHRH3LTA4HS1PR5 | |
| SCHEMBL5175580 | 0.87 | S1PR5 (0.61) | NPC1RAB9AHRH3LTA4HS1PR5 | |
| SCHEMBL451789 | 0.86 | NPC1 (0.59) | NPC1RAB9AHRH3LTA4HS1PR5 | |
| SCHEMBL5174917 | 0.85 | LTA4H (0.70) | NPC1RAB9AHRH3LTA4HFAAH | |
| SCHEMBL5175617 | 0.85 | LTA4H (0.77) | NPC1RAB9AHRH3LTA4HS1PR1 | |
| SCHEMBL5173797 | 0.84 | HRH3 (0.71) | NPC1RAB9AHRH3LTA4HS1PR5 | |
| SCHEMBL5175763 | 0.84 | S1PR5 (0.69) | NPC1RAB9AHRH3LTA4HS1PR5 | |
| SCHEMBL5175612 | 0.84 | RAB9A (0.74) | NPC1RAB9AHRH3LTA4HS1PR1 | |
| SCHEMBL5176478 | 0.84 | DRD2 (0.60) | NPC1RAB9AHRH3LTA4HS1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1868605-A2 | PHENYL AND PYRIDYL LTA4H MODULATORS | Janssen Pharmaceutica, N.V. (BE) | 2007-12-26 | — | — | EP | claimed |
| WO-2006105304-A2 | PHENYL AND PYRIDYL LTA4H MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-10-05 | — | — | WO | claimed |
| US-20060223792-A1 | Phenyl and pyridyl LTA4H modulators | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-10-05 | — | — | US | claimed |
| EP-1868605-A2 | PHENYL AND PYRIDYL LTA4H MODULATORS | Janssen Pharmaceutica, N.V. (BE) | 2007-12-26 | — | — | EP | disclosed |
| WO-2006105304-A2 | PHENYL AND PYRIDYL LTA4H MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-10-05 | — | — | WO | disclosed |
| US-20060223792-A1 | Phenyl and pyridyl LTA4H modulators | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-10-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060223792-A1 | Phenyl and pyridyl LTA4H modulators | LTA4H, LTB4R, LTC4S | NPC1 1667/4885RAB9A 4254/4885HRH3 159/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.