Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2376239 | 0.87 | ENPP2 (0.72) | ENPP2PTGS2 | |
| SCHEMBL10300269 | 0.79 | PTGS2 (0.62) | ENPP2PTGS2 | |
| SCHEMBL17548700 | 0.79 | ENPP2 (0.62) | ENPP2PTGS2 | |
| SCHEMBL7677302 | 0.79 | PTGS2 (0.62) | ENPP2PTGS2 | |
| SCHEMBL28182477 | 0.77 | GAA (0.65) | ENPP2PTGS2 | |
| SCHEMBL12807 | 0.77 | GAA (0.65) | ENPP2PTGS2 | |
| SCHEMBL8632609 | 0.75 | ALDH1A1 (0.55) | — | |
| SCHEMBL487226 | 0.74 | ENPP2 (0.56) | ENPP2PTGS2 | |
| Potassium Ion SCHEMBL1577376 | 0.74 | ENPP2 (0.56) | ENPP2PTGS2 | |
| SCHEMBL28027 | 0.74 | ENPP2 (0.56) | ENPP2PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 517 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107922350-B | Novel benzimidazole compounds and medicinal use thereof | 大日本住友制药株式会社 | 2022-04-19 | — | — | CN | claimed |
| EP-3348547-B1 | BENZIMIDAZOLE DERIVATIVES AS NAV 1.7 (SODIUM CHANNEL, VOLTAGE-GATED, TYPE IX, ALPHA SUBUNIT (SCN9A)) INHIBITORS FOR TREATING PAIN, DYSURIA AND MULTIPLE SCLEROSIS | SUMITOMO DAINIPPON PHARMA CO LTD (JP) | 2020-07-22 | — | — | EP | claimed |
| US-9522926-B2 | Activators of glucokinase | METABASIS THERAPEUTICS, INC. (US) | 2016-12-20 | — | — | US | claimed |
| US-20150119365-A1 | NOVEL ACTIVATORS OF GLUCOKINASE | CITIBANK, N.A., AS ADMINISTRATIVE AGENT | 2015-04-30 | — | — | US | claimed |
| EP-2185570-B1 | NOVEL ACTIVATORS OF GLUCOKINASE | METABASIS THERAPEUTICS INC (US) | 2014-03-19 | — | — | EP | claimed |
| EP-1702919-B1 | NOVEL 2-HETEROARYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVE | MSD KK (JP) | 2012-05-30 | — | — | EP | claimed |
| US-20110294758-A1 | NOVEL ACTIVATORS OF GLUCOKINASE | METABASIS THERAPEUTICS, INC. (US) | 2011-12-01 | — | — | US | claimed |
| JP-2010536773-A | — | — | 2010-12-02 | — | — | JP | claimed |
| EP-2185570-A2 | NOVEL ACTIVATORS OF GLUCOKINASE | Metabasis Therapeutics, Inc. (US) | 2010-05-19 | — | — | EP | claimed |
| WO-2009023718-A2 | NOVEL ACTIVATORS OF GLUCOKINASE | METABASIS THERAPEUTICS, INC. (US) | 2009-02-19 | — | — | WO | claimed |
| WO-1998043969-A1 | INDAZOLES OF CYCLIC UREAS USEFUL AS HIV PROTEASE INHIBITORS | DUPONT PHARMACEUTICALS COMPANY (US) | 1998-10-08 | — | — | WO | claimed |
| EP-0759929-A4 | OXIDATION OF STEROIDS HAVING ALLYLIC GROUPS | MERCK & CO INC (US) | 1998-09-30 | — | — | EP | claimed |
| EP-0759929-A1 | OXIDATION OF STEROIDS HAVING ALLYLIC GROUPS | Merck & Co., Inc. (a New Jersey corp.) (US) | 1997-03-05 | — | — | EP | claimed |
| WO-1995032215-A1 | OXIDATION OF STEROIDS HAVING ALLYLIC GROUPS | MERCK & CO., INC. (US) | 1995-11-30 | — | — | WO | claimed |
| EP-0339555-B1 | WATER SOLUBLE PREPARATIONS OF COCCIDIOSTATICS | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-12-23 | — | — | EP | claimed |
| US-5116990-A | MAGENTA DYE-FORMING COUPLER | FUJI PHOTO FILM CO., LTD. (JP) | 1992-05-26 | — | — | US | claimed |
| EP-0339555-A2 | Water soluble preparations of coccidiostatics | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-11-02 | — | — | EP | claimed |
| EP-0170164-B1 | SILVER HALIDE COLOR PHOTOGRAPHIC LIGHT-SENSITIVE MATERIAL | FUJI PHOTO FILM CO., LTD. (JP) | 1988-10-05 | — | — | EP | claimed |
| US-H122-H | PYRAZOLOAZOLE-TYPE MAGENTA COUPLER DISPERSED IN A HIGH-BOILING PHOSPHATE SOLVENT | FUJI PHOTO FILM CO., LTD. (JP) | 1986-09-02 | — | — | US | claimed |
| EP-0170164-A2 | Silver halide color photographic light-sensitive material | FUJI PHOTO FILM CO., LTD. (JP) | 1986-02-05 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150119365-A1 | NOVEL ACTIVATORS OF GLUCOKINASE | GCKR, GCK, HK1 | ENPP2 2324/4885PTGS2 1505/4885 |
| US-20110294758-A1 | NOVEL ACTIVATORS OF GLUCOKINASE | GCKR, GCK, HK1 | ENPP2 2324/4885PTGS2 1505/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.