Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | CTNNB1 | P35222 | 5/20 | 0.47 |
| ▸ | WNT3A | P56704 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13044823 | 0.86 | LMNA (0.69) | LMNAALDH1A1NPC1RAB9AMEN1 | |
| SCHEMBL14878250 | 0.82 | LMNA (0.62) | LMNAALDH1A1NPC1RAB9AMEN1 | |
| SCHEMBL13536765 | 0.81 | ALDH1A1 (0.61) | LMNAALDH1A1NPC1RAB9AMEN1 | |
| SCHEMBL13562555 | 0.81 | LMNA (0.61) | LMNAALDH1A1NPC1RAB9AMEN1 | |
| SCHEMBL471019 | 0.80 | ALDH1A1 (0.69) | LMNAALDH1A1NPC1RAB9AMEN1 | |
| SCHEMBL12719803 | 0.79 | LMNA (0.67) | LMNAALDH1A1NPC1RAB9AMEN1 | |
| Hydrochloric Acid SCHEMBL3303 | 0.79 | ALDH1A1 (0.67) | LMNAALDH1A1NPC1RAB9AMEN1 | |
| SCHEMBL28800151 | 0.78 | ALDH1A1 (0.61) | LMNAALDH1A1NPC1RAB9AMEN1 | |
| SCHEMBL13536701 | 0.77 | ALDH1A1 (0.65) | LMNAALDH1A1NPC1RAB9AMEN1 | |
| SCHEMBL5914971 | 0.77 | TSHR (0.56) | LMNAALDH1A1NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7294744-B2 | Process for manufacturing of enantiomerically pure 3-hydroxy-3-phenyl-propylamin | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2007-11-13 | — | — | US | claimed |
| EP-1789385-A1 | METHOD FOR PRODUCING N-ALKYL-N-METHYL-3-HYDROXY-3-(2-THIENYL)-PROPYLAMINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-05-30 | — | — | EP | claimed |
| WO-2005085192-A1 | METHOD FOR PRODUCING N-ALKYL-N-METHYL-3-HYDROXY-3-(2-THIENYL)-PROPYLAMINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-09-15 | — | — | WO | claimed |
| US-20050197503-A1 | Process for the preparation of N-alkyl-N-methyl-3-hydroxy-3-(2-thienyl)-propylamines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-09-08 | — | — | US | claimed |
| EP-1765766-B1 | METHOD FOR PRODUCING ENANTIOMERS 3-HYDROXY-3-PHENYL-PROPYLAMINES | BOEHRINGER INGELHEIM PHARMA (DE) | 2013-09-25 | — | — | EP | disclosed |
| EP-1789385-A1 | METHOD FOR PRODUCING N-ALKYL-N-METHYL-3-HYDROXY-3-(2-THIENYL)-PROPYLAMINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-05-30 | — | — | EP | disclosed |
| EP-1765766-A1 | METHOD FOR PRODUCING ENANTIOMERS 3-HYDROXY-3-PHENYL-PROPYLAMINES | Boehringer Ingelheim Pharma GmbH & Co. KG (DE) | 2007-03-28 | — | — | EP | disclosed |
| WO-2006005476-A1 | METHOD FOR PRODUCING ENANTIOMERS 3-HYDROXY-3-PHENYL-PROPYLAMINES | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2006-01-19 | — | — | WO | disclosed |
| WO-2005085192-A1 | METHOD FOR PRODUCING N-ALKYL-N-METHYL-3-HYDROXY-3-(2-THIENYL)-PROPYLAMINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-09-15 | — | — | WO | disclosed |
| US-20050197503-A1 | Process for the preparation of N-alkyl-N-methyl-3-hydroxy-3-(2-thienyl)-propylamines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197503-A1 | Process for the preparation of N-alkyl-N-methyl-3-hydroxy-3-(2-thienyl)-propylamines | HNMT, PNMT, HRH4 | LMNA 3996/4885ALDH1A1 4097/4885NPC1 3703/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.