SCHEMBL5190280

SCHEMBL5190280

CCCN1c2ccc(OC)cc2C(C)(C)C12C=Nc1c(ccc3ncccc13)O2

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.51
THRB P10828 5/20 0.51
SMN1; SMN2 Q16637 4/20 0.51
KDM4E B2RXH2 4/20 0.51
LMNA P02545 3/20 0.51
ALDH1A1 P00352 2/20 0.51
HPGD P15428 2/20 0.51
HTT P42858 2/20 0.51
GAA P10253 2/20 0.51
ALOX12 P18054 2/20 0.51
RECQL P46063 2/20 0.51
TDP1 Q9NUW8 2/20 0.51
L3MBTL1 Q9Y468 2/20 0.51
POLB P06746 1/20 0.51
MAPK1 P28482 1/20 0.51
PKM P14618 2/20 0.41
MEN1 O00255 1/20 0.41
PLIN1 O60240 1/20 0.41
TSHR P16473 1/20 0.41
PLIN5 Q00G26 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14902888 0.89 MAPT (0.43) MAPTTHRBSMN1; SMN2KDM4ELMNA
SCHEMBL10420203 0.88 MAPT (0.65) MAPTTHRBSMN1; SMN2KDM4ELMNA
SCHEMBL8717639 0.86 KDM4E (0.43) MAPTTHRBSMN1; SMN2KDM4ELMNA
SCHEMBL9115489 0.80 KDM4E (0.39) MAPTTHRBSMN1; SMN2KDM4ELMNA
SCHEMBL8717565 0.78 MAPT (0.62) MAPTTHRBSMN1; SMN2KDM4ELMNA
SCHEMBL7638287 0.77 ALDH1A1 (0.50) MAPTTHRBSMN1; SMN2KDM4ELMNA
SCHEMBL2397763 0.75 MAPT (0.54) MAPTTHRBSMN1; SMN2KDM4ELMNA
SCHEMBL7634456 0.75 MAPT (0.48) MAPTTHRBSMN1; SMN2KDM4ELMNA
SCHEMBL9996010 0.74 MAPT (0.80) MAPTTHRBSMN1; SMN2KDM4ELMNA
SCHEMBL10418850 0.74 MAPT (0.46) MAPTTHRBSMN1; SMN2KDM4ELMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0397803-B1 VARIABLE-LIGHT TRANSMITTANCE ARTICLE AND METHOD FOR PREPARING SAME PPG INDUSTRIES INC (US) 1994-03-02 EP claimed
EP-2066714-B1 ABRASION AND/OR SCRATCH RESISTANT ARTICLE COMPRISING AN IMPACT RESISTANT PHOTOCHROMIC POLYURETHANE COATING, AND PROCESS OF PREPARATION THEREOF ESSILOR INT (FR) 2018-04-11 EP disclosed
US-20130108858-A1 Methods for Making an Article Coated with a Photochromic Film and Use Thereof in Ophthalmological Optics Essilor International (Compagnie Generate d Optique (FR) 2013-05-02 US disclosed
US-20130108858-A1 Methods for Making an Article Coated with a Photochromic Film and Use Thereof in Ophthalmological Optics Essilor International (Compagnie Generate d Optique (FR) 2013-05-02 US disclosed
US-20100119802-A1 Abrasion and/or Scratch Resistant Article Comprising an Impact Resistant Photochromic Polyurethane Coating, and Process of Preparation Thereof FORD CHRISTY 2010-05-13 US disclosed
US-7662433-B2 impact resistant, abrasion and/or scratch resistant photochromic article comprising a substrate having two main faces, comprising: preparing a curable coating composition comprising at least one unblocked polyisocyanate terminated polyurethane pre-polymer, at least one polyol and a photochromic article ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D'OPTIQUE) (FR) 2010-02-16 US disclosed
WO-2008031879-A1 ABRASION AND/OR SCRATCH RESISTANT ARTICLE COMPRISING AN IMPACT RESISTANT PHOTOCHROMIC POLYURETHANE COATING, AND PROCESS OF PREPARATION THEREOF ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D'OPTIQUE) (FR) 2008-03-20 WO disclosed
US-20080067701-A1 Abrasion and/or Scratch Resistant Article Comprising an Impact Resistant Photochromic Polyurethane Coating, and Process of Preparation Thereof ESSILOR INTERNATIONAL (FR) 2008-03-20 US disclosed
WO-2007088312-A1 METHODS FOR MAKING AN ARTICLE COATED WITH A PHOTOCHROMIC FILM AND USE THEREOF IN OPHTHALMOLOGICAL OPTICS ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D'OPTIQUE) (FR) 2007-08-09 WO disclosed
EP-0890119-B1 PHOTOCHROMIC NAPHTHOPYRAN COMPOSITIONS OF NEUTRAL COLOR TRANSITIONS OPTICAL INC (US) 2007-06-20 EP disclosed
US-7157518-B2 Method for preparing an organo-silicon sol and materials obtained from such a sol ESSILOR INTERNATIONAL COMPAGNIE GENERALE D'OPTIQUE (FR) 2007-01-02 US disclosed
US-7157518-B2 Method for preparing an organo-silicon sol and materials obtained from such a sol ESSILOR INTERNATIONAL COMPAGNIE GENERALE D'OPTIQUE (FR) 2007-01-02 US disclosed
WO-1995016731-A1 COATING COMPOSITION AND ARTICLES HAVING A CURED COATING PPG INDUSTRIES, INC. (US) 1995-06-22 WO disclosed
EP-0480932-B1 PHOTOCHROMIC POLYMERIC ARTICLE PPG INDUSTRIES INC (US) 1994-06-29 EP disclosed
US-5110881-A Polymerizable organic resin composition PPG INDUSTRIES, INC. (US) 1992-05-05 US disclosed
EP-0480932-A1 PHOTOCHROMIC POLYMERIC ARTICLE. PPG INDUSTRIES INC (US) 1992-04-22 EP disclosed
US-4994208-A Curable blend of allyl carbonate, acrylated polyurethane and allyl acrylates PPG INDUSTRIES, INC. (US) 1991-02-19 US disclosed
WO-1990012819-A1 PHOTOCHROMIC POLYMERIC ARTICLE PPG INDUSTRIES, INC. (US) 1990-11-01 WO disclosed