Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | THRB | P10828 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14902888 | 0.90 | MAPT (0.43) | KDM4EMAPTTHRBSMN1; SMN2ALOX12 | |
| SCHEMBL2397763 | 0.88 | MAPT (0.54) | KDM4EMAPTTHRBSMN1; SMN2ALOX12 | |
| SCHEMBL5190280 | 0.86 | MAPT (0.51) | KDM4EMAPTTHRBSMN1; SMN2ALOX12 | |
| SCHEMBL9115489 | 0.84 | KDM4E (0.39) | KDM4EMAPTTHRBSMN1; SMN2ALOX12 | |
| SCHEMBL2401836 | 0.82 | KDM4E (0.44) | KDM4EMAPTTHRBSMN1; SMN2ALOX12 | |
| SCHEMBL8717565 | 0.79 | MAPT (0.62) | KDM4EMAPTTHRBSMN1; SMN2ALOX12 | |
| SCHEMBL7117468 | 0.76 | MAPT (0.72) | KDM4EMAPTTHRBSMN1; SMN2ALOX12 | |
| SCHEMBL29493000 | 0.76 | MAPT (0.72) | KDM4EMAPTTHRBSMN1; SMN2ALOX12 | |
| SCHEMBL10552518 | 0.75 | MAPT (0.55) | KDM4EMAPTTHRBSMN1; SMN2ALOX12 | |
| SCHEMBL9866811 | 0.75 | KDM4E (0.43) | KDM4EMAPTTHRBSMN1; SMN2ALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066714-B1 | ABRASION AND/OR SCRATCH RESISTANT ARTICLE COMPRISING AN IMPACT RESISTANT PHOTOCHROMIC POLYURETHANE COATING, AND PROCESS OF PREPARATION THEREOF | ESSILOR INT (FR) | 2018-04-11 | — | — | EP | disclosed |
| US-20140209842-A1 | SILICONE MATERIAL HAVING A PHOTOCHROMIC ADDITIVE | LUXES BRAND, INCORPORATION (US) | 2014-07-31 | — | — | US | disclosed |
| US-20130108858-A1 | Methods for Making an Article Coated with a Photochromic Film and Use Thereof in Ophthalmological Optics | Essilor International (Compagnie Generate d Optique (FR) | 2013-05-02 | — | — | US | disclosed |
| US-20130108858-A1 | Methods for Making an Article Coated with a Photochromic Film and Use Thereof in Ophthalmological Optics | Essilor International (Compagnie Generate d Optique (FR) | 2013-05-02 | — | — | US | disclosed |
| US-20100119802-A1 | Abrasion and/or Scratch Resistant Article Comprising an Impact Resistant Photochromic Polyurethane Coating, and Process of Preparation Thereof | FORD CHRISTY | 2010-05-13 | — | — | US | disclosed |
| US-20100119802-A1 | Abrasion and/or Scratch Resistant Article Comprising an Impact Resistant Photochromic Polyurethane Coating, and Process of Preparation Thereof | FORD CHRISTY | 2010-05-13 | — | — | US | disclosed |
| US-7662433-B2 | impact resistant, abrasion and/or scratch resistant photochromic article comprising a substrate having two main faces, comprising: preparing a curable coating composition comprising at least one unblocked polyisocyanate terminated polyurethane pre-polymer, at least one polyol and a photochromic article | ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D'OPTIQUE) (FR) | 2010-02-16 | — | — | US | disclosed |
| US-7662433-B2 | impact resistant, abrasion and/or scratch resistant photochromic article comprising a substrate having two main faces, comprising: preparing a curable coating composition comprising at least one unblocked polyisocyanate terminated polyurethane pre-polymer, at least one polyol and a photochromic article | ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D'OPTIQUE) (FR) | 2010-02-16 | — | — | US | disclosed |
| US-7608207-B2 | Forming a hydrophilic polyurethane prepolymer with isocyanate end groups, mixing with a photochromic agent; adding water or a mixture of water and solvent, under agitation to form emulsion; adding chain extension agent | ESSILOR INTERNATIONAL COMPAGNIE GENERALE D'OPTIQUE (FR) | 2009-10-27 | — | — | US | disclosed |
| US-7608207-B2 | Forming a hydrophilic polyurethane prepolymer with isocyanate end groups, mixing with a photochromic agent; adding water or a mixture of water and solvent, under agitation to form emulsion; adding chain extension agent | ESSILOR INTERNATIONAL COMPAGNIE GENERALE D'OPTIQUE (FR) | 2009-10-27 | — | — | US | disclosed |
| WO-2008031879-A1 | ABRASION AND/OR SCRATCH RESISTANT ARTICLE COMPRISING AN IMPACT RESISTANT PHOTOCHROMIC POLYURETHANE COATING, AND PROCESS OF PREPARATION THEREOF | ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D'OPTIQUE) (FR) | 2008-03-20 | — | — | WO | disclosed |
| US-20080067701-A1 | Abrasion and/or Scratch Resistant Article Comprising an Impact Resistant Photochromic Polyurethane Coating, and Process of Preparation Thereof | ESSILOR INTERNATIONAL (FR) | 2008-03-20 | — | — | US | disclosed |
| US-20080067701-A1 | Abrasion and/or Scratch Resistant Article Comprising an Impact Resistant Photochromic Polyurethane Coating, and Process of Preparation Thereof | ESSILOR INTERNATIONAL (FR) | 2008-03-20 | — | — | US | disclosed |
| WO-2007088312-A1 | METHODS FOR MAKING AN ARTICLE COATED WITH A PHOTOCHROMIC FILM AND USE THEREOF IN OPHTHALMOLOGICAL OPTICS | ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D'OPTIQUE) (FR) | 2007-08-09 | — | — | WO | disclosed |
| EP-0785936-A4 | PHOTOCHROMIC NAPHTHOXAZINE COMPOUNDS | PPG INDUSTRIES INC (US) | 1998-07-08 | — | — | EP | disclosed |
| EP-0785936-A1 | PHOTOCHROMIC NAPHTHOXAZINE COMPOUNDS | PPG INDUSTRIES, INC. (US) | 1997-07-30 | — | — | EP | disclosed |
| WO-1995016731-A1 | COATING COMPOSITION AND ARTICLES HAVING A CURED COATING | PPG INDUSTRIES, INC. (US) | 1995-06-22 | — | — | WO | disclosed |