Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 6/20 | 0.56 |
| ▸ | MMP9 | P14780 | 6/20 | 0.56 |
| ▸ | MMP8 | P22894 | 6/20 | 0.56 |
| ▸ | MMP13 | P45452 | 5/20 | 0.56 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.50 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.50 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.48 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | STAT1 | P42224 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2982443 | 0.85 | MMP2 (0.48) | MMP2MMP9MMP8MMP13RAB9A | |
| SCHEMBL5211404 | 0.84 | KMT2A (0.58) | RAB9ANPC1MAPTNPBWR1MEN1 | |
| SCHEMBL19739335 | 0.80 | MMP2 (0.53) | MMP2MMP9MMP8MMP13RAB9A | |
| SCHEMBL5191194 | 0.79 | MAPT (0.49) | RAB9ANPC1MAPTMEN1KMT2A | |
| SCHEMBL5190850 | 0.79 | TUBB4A (0.43) | RAB9ANPC1MAPTMEN1GAA | |
| SCHEMBL5205370 | 0.79 | ALDH1A1 (0.48) | MAPTCHEK2MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5191764 | 0.79 | SIRT2 (0.52) | RAB9ANPC1MAPTCHEK2LMNA | |
| SCHEMBL25826318 | 0.78 | NPC1 (0.68) | MMP2MMP9MMP8MMP13RAB9A | |
| SCHEMBL6526357 | 0.78 | MMP2 (0.70) | MMP2MMP9MMP8MMP13RAB9A | |
| SCHEMBL19739144 | 0.77 | MMP2 (0.60) | MMP2MMP9MMP8MMP13RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831218-A2 | CARBAMATE SUBSTITUTED IMIDAZO- AND PYRROLO-PYRIDINES AS PROTEIN KINASE INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066914-A2 | CARBAMATE SUBSTITUTED IMIDAZO- AND PYRROLO-PYRIDINES AS PROTEIN KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-06-29 | — | — | WO | disclosed |