Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | SCD | O00767 | 4/20 | 0.47 |
| ▸ | HPSE | Q9Y251 | 2/20 | 0.45 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | BAZ1A | Q9NRL2 | 1/20 | 0.43 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.42 |
| ▸ | TUBB | P07437 | 1/20 | 0.42 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.42 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.42 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.42 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.42 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.42 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.42 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2975556 | 0.84 | KMT2A (0.47) | KMT2AMEN1NPC1RAB9ASCD | |
| SCHEMBL5190791 | 0.84 | MMP2 (0.56) | KMT2AMEN1NPC1RAB9ANPBWR1 | |
| SCHEMBL5191194 | 0.80 | MAPT (0.49) | KMT2AMEN1NPC1RAB9AHPSE | |
| SCHEMBL5190850 | 0.80 | TUBB4A (0.43) | KMT2AMEN1NPC1RAB9AHPSE | |
| SCHEMBL5205370 | 0.79 | ALDH1A1 (0.48) | KMT2AMEN1MAPTSMN1; SMN2 | |
| SCHEMBL5191764 | 0.79 | SIRT2 (0.52) | NPC1RAB9ATP53MAPTSMN1; SMN2 | |
| SCHEMBL5202947 | 0.78 | MEN1 (0.50) | KMT2AMEN1NPC1RAB9AHPSE | |
| SCHEMBL5190813 | 0.77 | HDAC6 (0.57) | TP53MAPTSMN1; SMN2 | |
| SCHEMBL5213390 | 0.76 | KDM4E (0.48) | KMT2AMEN1NPC1RAB9ATP53 | |
| SCHEMBL2971334 | 0.76 | CA2 (0.41) | KMT2AMEN1NPC1RAB9ATUBB4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831218-A2 | CARBAMATE SUBSTITUTED IMIDAZO- AND PYRROLO-PYRIDINES AS PROTEIN KINASE INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066914-A2 | CARBAMATE SUBSTITUTED IMIDAZO- AND PYRROLO-PYRIDINES AS PROTEIN KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-06-29 | — | — | WO | disclosed |