SCHEMBL5190875

SCHEMBL5190875

NC(=O)C1CN(Cc2cccnc2)CCN1

nearest known ligand 0.57

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.49
MAPT P10636 1/20 0.49
HTT P42858 1/20 0.49
CHRNB2 P17787 1/20 0.49
CHRNA4 P43681 1/20 0.49
SIRT2 Q8IXJ6 1/20 0.48
SIRT1 Q96EB6 1/20 0.48
MAPK1 P28482 1/20 0.47
KDM4E B2RXH2 4/20 0.46
KMT2A Q03164 3/20 0.44
SIGMAR1 Q99720 1/20 0.44
TDP1 Q9NUW8 2/20 0.43
PARP1 P09874 1/20 0.43
PARP2 Q9UGN5 1/20 0.43
SLC18A3 Q16572 1/20 0.42
MEN1 O00255 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27802495 0.90 CHRNB2 (0.51) ALDH1A1MAPTHTTCHRNB2CHRNA4
SCHEMBL27779058 0.89 ALDH1A1 (0.53) ALDH1A1MAPTHTTCHRNB2CHRNA4
SCHEMBL27778860 0.89 ALDH1A1 (0.53) ALDH1A1MAPTHTTCHRNB2CHRNA4
SCHEMBL27778861 0.89 ALDH1A1 (0.53) ALDH1A1MAPTHTTCHRNB2CHRNA4
SCHEMBL13535271 0.88 KMT2A (0.49) ALDH1A1MAPTHTTCHRNB2CHRNA4
SCHEMBL7808456 0.84 SIGMAR1 (0.49) ALDH1A1SIRT1KDM4EKMT2ASIGMAR1
SCHEMBL5191569 0.83 ALDH1A1 (0.47) ALDH1A1MAPTHTTCHRNB2CHRNA4
SCHEMBL29976288 0.82 ALDH1A1 (0.44) ALDH1A1MAPTHTTCHRNB2CHRNA4
SCHEMBL13535512 0.79 CHRNB2 (0.56) ALDH1A1MAPTHTTCHRNB2CHRNA4
SCHEMBL30471711 0.77 MLNR (0.51)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2015097667-A2 A COMPOSITION, PROCESS OF PREPARATION OF SAID COMPOSITION, KIT AND A METHOD OF TREATING CANCER CELLWORKS GROUP, INC., (US) 2015-07-02 WO disclosed
EP-0968206-B8 N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS BERLEX INC (US) 2007-01-24 EP disclosed
EP-0968206-A1 N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS BERLEX LABORATORIES, INC. (US) 2000-01-05 EP disclosed
WO-1998037079-A1 N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS BERLEX LABORATORIES, INC. (US) 1998-08-27 WO disclosed