Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5191096 | 0.77 | ALDH1A1 (0.46) | ALDH1A1PKML3MBTL1MAPK1 | |
| SCHEMBL10681973 | 0.75 | SIGMAR1 (0.55) | SIGMAR1ALDH1A1MEN1KMT2APOLB | |
| SCHEMBL5214033 | 0.73 | SIGMAR1 (0.49) | SIGMAR1POLBL3MBTL1GAA | |
| SCHEMBL5193050 | 0.72 | KMT2A (0.41) | ALDH1A1HTTPKMMEN1KMT2A | |
| SCHEMBL22790774 | 0.71 | ALDH1A1 (0.68) | SIGMAR1ALDH1A1MEN1KMT2APOLB | |
| SCHEMBL5195061 | 0.70 | SIGMAR1 (0.49) | SIGMAR1ALDH1A1PKMMEN1KMT2A | |
| SCHEMBL26024178 | 0.70 | RORC (0.51) | SIGMAR1ALDH1A1HTTPKMMEN1 | |
| SCHEMBL5199484 | 0.69 | MAPT (0.51) | PKMMEN1KMT2APOLBMAPT | |
| SCHEMBL5191582 | 0.69 | TP53 (0.56) | PKMMEN1KMT2APOLBMAPT | |
| SCHEMBL26024193 | 0.69 | SIGMAR1 (0.54) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0968206-B8 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX INC (US) | 2007-01-24 | — | — | EP | disclosed |
| EP-0968206-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 2000-01-05 | — | — | EP | disclosed |
| WO-1998037079-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 1998-08-27 | — | — | WO | disclosed |