Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | CCR2 | P41597 | 7/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | CCR5 | P51681 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5193943 | 0.91 | PDGFRB (0.44) | PDGFRBSHMT2L3MBTL1CCR2KCNH2 | |
| SCHEMBL5193461 | 0.82 | HIF1A (0.40) | TP53MEN1KMT2A | |
| SCHEMBL5213600 | 0.81 | ALDH1A1 (0.51) | SHMT2MAPTSMN1; SMN2LMNAMEN1 | |
| SCHEMBL5193973 | 0.78 | MAPT (0.47) | PDGFRBSHMT2L3MBTL1CCR2MAPT | |
| SCHEMBL5193490 | 0.78 | FAAH (0.50) | PDGFRBSHMT2L3MBTL1MAPTNPSR1 | |
| SCHEMBL5193931 | 0.78 | HIF1A (0.42) | L3MBTL1 | |
| SCHEMBL5190799 | 0.77 | PDGFRB (0.42) | PDGFRBSHMT2L3MBTL1CCR2KCNH2 | |
| SCHEMBL5190772 | 0.77 | OGA (0.46) | MAPTTP53SMN1; SMN2NPSR1LMNA | |
| SCHEMBL5210351 | 0.76 | FAAH (0.46) | CCR2KCNH2MAPTTP53LMNA | |
| SCHEMBL5192582 | 0.75 | FAAH (0.50) | CCR2KCNH2MAPTTP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0968206-B8 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX INC (US) | 2007-01-24 | — | — | EP | claimed |
| EP-0968206-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 2000-01-05 | — | — | EP | claimed |
| WO-1998037079-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 1998-08-27 | — | — | WO | claimed |