Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | CCR2 | P41597 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5190772 | 0.80 | OGA (0.46) | MAPTSMN1; SMN2ALDH1A1KMT2ABLM | |
| SCHEMBL5191970 | 0.80 | MAPT (0.49) | MAPTSMN1; SMN2KMT2ABLMCCR2 | |
| SCHEMBL5193553 | 0.78 | PDGFRB (0.45) | MAPTSMN1; SMN2SHMT2KMT2AL3MBTL1 | |
| SCHEMBL5193442 | 0.75 | MAPT (0.55) | MAPTSMN1; SMN2KMT2ABLMFAAH | |
| SCHEMBL5193490 | 0.75 | FAAH (0.50) | MAPTSHMT2L3MBTL1PDGFRBATM | |
| SCHEMBL5193943 | 0.72 | PDGFRB (0.44) | MAPTSMN1; SMN2SHMT2KMT2AL3MBTL1 | |
| SCHEMBL5190799 | 0.72 | PDGFRB (0.42) | MAPTSHMT2KMT2AL3MBTL1PDGFRB | |
| SCHEMBL5199484 | 0.72 | MAPT (0.51) | MAPTSMN1; SMN2KMT2ABLMFAAH | |
| SCHEMBL5193461 | 0.72 | HIF1A (0.40) | ALDH1A1KMT2AMEN1 | |
| SCHEMBL5213600 | 0.72 | ALDH1A1 (0.51) | MAPTSMN1; SMN2SHMT2ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0968206-B8 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX INC (US) | 2007-01-24 | — | — | EP | claimed |
| EP-0968206-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 2000-01-05 | — | — | EP | claimed |
| WO-1998037079-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 1998-08-27 | — | — | WO | claimed |