Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OGA | O60502 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | BMP1 | P13497 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5193973 | 0.80 | MAPT (0.47) | MAPTSMN1; SMN2ALDH1A1BLMMEN1 | |
| SCHEMBL5193553 | 0.77 | PDGFRB (0.45) | MAPTSMN1; SMN2LMNATP53MEN1 | |
| SCHEMBL5191970 | 0.77 | MAPT (0.49) | MAPTSMN1; SMN2BLMLMNAPKM | |
| SCHEMBL5194017 | 0.74 | ALDH1A1 (0.41) | SMN1; SMN2ALDH1A1TP53PKMMEN1 | |
| SCHEMBL5193442 | 0.72 | MAPT (0.55) | MAPTSMN1; SMN2BLMRAB9AMEN1 | |
| SCHEMBL5193461 | 0.71 | HIF1A (0.40) | ALDH1A1TP53MEN1KMT2AMAPK1 | |
| SCHEMBL5213600 | 0.71 | ALDH1A1 (0.51) | MAPTSMN1; SMN2ALDH1A1LMNANPC1 | |
| SCHEMBL5193490 | 0.70 | FAAH (0.50) | MAPTTHRBHTTNPSR1 | |
| SCHEMBL5199484 | 0.69 | MAPT (0.51) | MAPTSMN1; SMN2BLMPKMTSHR | |
| SCHEMBL5194086 | 0.68 | FAAH (0.62) | MAPTSMN1; SMN2RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0968206-B8 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX INC (US) | 2007-01-24 | — | — | EP | claimed |
| EP-0968206-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 2000-01-05 | — | — | EP | claimed |
| WO-1998037079-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 1998-08-27 | — | — | WO | claimed |