Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | HPGD | P15428 | 5/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | GFER | P55789 | 2/20 | 0.43 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | RAPGEF3 | O95398 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5194094 | 0.85 | ALDH1A1 (0.53) | ALDH1A1HPGDHSD17B10GAAMAPT | |
| SCHEMBL5193555 | 0.84 | KMT2A (0.55) | ALDH1A1HPGDGAAMAPTKDM4E | |
| SCHEMBL5196570 | 0.78 | MAPT (0.45) | ALDH1A1HPGDGAAMAPTKMT2A | |
| SCHEMBL3812615 | 0.78 | ALDH1A1 (0.50) | ALDH1A1HPGDHSD17B10GAAMAPT | |
| SCHEMBL3816881 | 0.78 | ALDH1A1 (0.56) | ALDH1A1HPGDHSD17B10GAAKDM4E | |
| SCHEMBL5194075 | 0.73 | SMN1; SMN2 (0.53) | ALDH1A1HPGDGAAMAPTKDM4E | |
| SCHEMBL5196804 | 0.73 | LMNA (0.53) | ALDH1A1HPGDGAAMAPTKDM4E | |
| SCHEMBL3816978 | 0.71 | ALDH1A1 (0.52) | ALDH1A1HPGDHSD17B10GAAKMT2A | |
| SCHEMBL5193948 | 0.70 | TRPM8 (0.47) | ALDH1A1HPGDGAAMAPTKDM4E | |
| SCHEMBL3809030 | 0.70 | ALDH1A1 (0.46) | ALDH1A1HPGDHSD17B10GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1321463-B1 | Thiazole derivatives and their use for the treatment or prevention of Flavivirus infections | VIROCHEM PHARMA INC (CA) | 2007-08-08 | — | — | EP | claimed |