Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | CRHBP | P24387 | 2/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA3 | P07451 | 1/20 | 0.43 |
| ▸ | CA4 | P22748 | 1/20 | 0.43 |
| ▸ | CA6 | P23280 | 1/20 | 0.43 |
| ▸ | CA5A | P35218 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5721087 | 0.86 | GLS (0.43) | GLSHPGDLMNATSHRKMT2A | |
| SCHEMBL819828 | 0.82 | KMT2A (0.58) | GLSHPGDLMNATSHRKMT2A | |
| SCHEMBL2016945 | 0.82 | CYP2C19 (0.52) | GLSHPGDLMNATSHRKMT2A | |
| SCHEMBL2049579 | 0.80 | ALDH1A1 (0.66) | LMNAKMT2AALDH1A1CRHBPCRHR2 | |
| SCHEMBL2721958 | 0.80 | LMNA (0.50) | GLSLMNAALDH1A1CRHBPCRHR2 | |
| SCHEMBL819824 | 0.79 | GLS (0.46) | GLSHPGDLMNATSHRKMT2A | |
| SCHEMBL6802549 | 0.79 | EPHX1 (0.58) | GLSHPGDTSHRKMT2AALDH1A1 | |
| SCHEMBL19256857 | 0.79 | ROCK2 (0.50) | GLSLMNAALDH1A1CRHBPCRHR2 | |
| SCHEMBL9055208 | 0.79 | ROCK2 (0.50) | GLSLMNAALDH1A1CRHBPCRHR2 | |
| SCHEMBL7504901 | 0.79 | LMNA (0.49) | LMNAALDH1A1CRHBPCRHR2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1737840-A1 | 1-AMINO-PHTHALAZINE DERIVATIVES, THE PREPARATION AND THE THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2007-01-03 | — | — | EP | disclosed |
| WO-2005103033-A1 | 1-AMINO-PHTHALAZINE DERIVATIVES, THE PREPARATION AND THE THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2005-11-03 | — | — | WO | disclosed |