Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.30 |
| ▸ | LMNA | P02545 | 2/20 | 0.30 |
| ▸ | BLM | P54132 | 2/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6633848 | 0.84 | KDM4E (0.32) | ALDH1A1KDM4E | |
| SCHEMBL6634950 | 0.82 | KDM4E (0.34) | ALDH1A1KDM4EMAPTHSD17B10CYP2D6 | |
| SCHEMBL6633356 | 0.78 | KDM4E (0.37) | ALDH1A1KDM4EMAPTHSD17B10CYP2D6 | |
| SCHEMBL6636875 | 0.75 | CYP19A1 (0.42) | ALDH1A1KDM4EMAPTLMNARAB9A | |
| SCHEMBL5217655 | 0.74 | TBXAS1 (0.31) | — | |
| SCHEMBL6632885 | 0.73 | HTT (0.41) | ALDH1A1KDM4EHSD17B10LMNATSHR | |
| SCHEMBL1667203 | 0.67 | KDM4E (0.41) | KDM4ETSHR | |
| SCHEMBL31076264 | 0.67 | KDM4E (0.41) | KDM4ETSHR | |
| SCHEMBL1667202 | 0.67 | KDM4E (0.41) | KDM4ETSHR | |
| Hydrochloric Acid SCHEMBL2521887 | 0.66 | KDM4E (0.40) | KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812431-A1 | 4-(PYRAZINE-2-YL)-PYRROLIDINE-2-CARBOXYLIC ACID COMPOUNDS AND DERIVATIVES THEREOF AS HEPATITIS C VIRUS INHIBITORS | GLAXO GROUP LIMITED (GB) | 2007-08-01 | — | — | EP | disclosed |
| WO-2007039145-A1 | C (2) -HETEROARYLMETHYL-C (4) -PYRAZINYL-2-YL ACYL PYRROLIDINE COMPOUNDS AND THEIR USE FOR TREATING VIRAL INFECTIONS, ESPECIALLY HEPATITIS C VIRUS | GLAXO GROUP LIMITED (GB) | 2007-04-12 | — | — | WO | disclosed |
| WO-2007039143-A1 | C (2) -HETEROARYLMETHYL-C (4) -PYRAZIN-2-YL ACYL PYRROLIDINE COMPOUNDS AND THEIR USER FOR TREATING VIRAL INFECTIONS, ESPECIALLY HEPATITICS C (HCV) | GLAXO GROUP LIMITED (GB) | 2007-04-12 | — | — | WO | disclosed |
| WO-2006045615-A1 | 4- (PYRAZINE-2-YL) -PYRROLIDINE-2-CARBOXYLIC ACID COMPOUNDS AND DERIVATIVES THEREOF AS HEPATITIS C VIRUS INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-05-04 | — | — | WO | disclosed |