Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | UBE2M | P61081 | 6/20 | 0.36 |
| ▸ | DCUN1D1 | Q96GG9 | 6/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | SCD | O00767 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6633356 | 0.80 | KDM4E (0.37) | RAB9ASMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL6636875 | 0.76 | CYP19A1 (0.42) | NPC1RAB9ASMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL6633848 | 0.74 | KDM4E (0.32) | ALDH1A1KDM4E | |
| SCHEMBL5196351 | 0.73 | ALDH1A1 (0.33) | RAB9AMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL5214156 | 0.73 | MAPT (0.36) | HTTNPC1RAB9ASMN1; SMN2PKM | |
| SCHEMBL3902204 | 0.68 | ALDH1A1 (0.47) | HTTNPC1RAB9ASMN1; SMN2PKM | |
| SCHEMBL907510 | 0.63 | KMT2A (0.51) | HTTSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL1667203 | 0.63 | KDM4E (0.41) | TSHRKDM4E | |
| SCHEMBL31076264 | 0.63 | KDM4E (0.41) | TSHRKDM4E | |
| SCHEMBL1667202 | 0.63 | KDM4E (0.41) | TSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1440069-A1 | 4-(6-MEMBERED)-HETEROARYL ACYL PYRROLIDINE DERIVATIVES AS HCV INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-07-28 | — | — | EP | disclosed |
| WO-2003037895-A1 | 4-(6-MEMBERED)-HETEROARYL ACYL PYRROLIDINE DERIVATIVES AS HCV INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-05-08 | — | — | WO | disclosed |