Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOBEC3A | P31941 | 3/20 | 0.42 |
| ▸ | APOBEC3G | Q9HC16 | 3/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.41 |
| ▸ | PRCP | P42785 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14537683 | 0.66 | DDB1 (0.50) | ALDH1A1 | |
| SCHEMBL10553437 | 0.64 | PRKCA (0.33) | APOBEC3AAPOBEC3GSIGMAR1PRCPALDH1A1 | |
| SCHEMBL5196881 | 0.64 | MCL1 (0.35) | ALDH1A1MEN1KMT2ACHRM2CHRM1 | |
| SCHEMBL14214939 | 0.63 | OPRM1 (0.51) | SIGMAR1PRCPSLC22A1SMN1; SMN2 | |
| SCHEMBL26565550 | 0.63 | MTNR1A (0.44) | ALDH1A1HTTMEN1KMT2A | |
| SCHEMBL14214940 | 0.61 | HDAC9 (0.47) | APOBEC3AAPOBEC3GSIGMAR1PRCPALDH1A1 | |
| SCHEMBL20625157 | 0.61 | KCNA3 (0.30) | — | |
| SCHEMBL14968336 | 0.61 | PRCP (0.48) | APOBEC3AAPOBEC3GSIGMAR1PRCPALDH1A1 | |
| SCHEMBL9961316 | 0.60 | APOBEC3A (0.63) | APOBEC3AAPOBEC3GSIGMAR1PRCPALDH1A1 | |
| SCHEMBL21297490 | 0.60 | DDB1 (0.43) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773758-A1 | OXIME DERIVATIVE HYDROXYETHYLAMINE ASPARTYL-PROTEASE INHIBITORS | Elan Pharmaceuticals, Inc. (US) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006010094-A1 | OXIME DERIVATIVE HYDROXYETHYLAMINE ASPARTYL-PROTEASE INHIBITORS | ELAN PHARMACEUTICALS, INC. (US) | 2006-01-26 | — | — | WO | disclosed |