Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 6/20 | 0.52 |
| ▸ | DBF4 | Q9UBU7 | 6/20 | 0.52 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.51 |
| ▸ | GRM6 | O15303 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HPGDS | O60760 | 1/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | LHCGR | P22888 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16312760 | 0.84 | SMN1; SMN2 (0.66) | CDC7DBF4TRPM8SMN1; SMN2ALDH1A1 | |
| SCHEMBL1726531 | 0.84 | TRPM8 (0.71) | CDC7DBF4TRPM8GRM6SMN1; SMN2 | |
| SCHEMBL27935666 | 0.81 | CDC7 (0.78) | CDC7DBF4TRPM8SMN1; SMN2ALDH1A1 | |
| SCHEMBL7759391 | 0.77 | NPC1 (0.70) | SMN1; SMN2MAPTHPGDCDK2NPC1 | |
| SCHEMBL2481891 | 0.76 | L3MBTL1 (0.49) | CDC7DBF4TRPM8GRM6SMN1; SMN2 | |
| SCHEMBL27891114 | 0.75 | GRM6 (0.56) | GRM6SMN1; SMN2ALDH1A1GAAMAPT | |
| SCHEMBL28861577 | 0.74 | LMNA (0.42) | CDC7DBF4GRM6SMN1; SMN2ALDH1A1 | |
| SCHEMBL5193754 | 0.74 | TRPM8 (0.53) | TRPM8SMN1; SMN2ALDH1A1GAAMAPT | |
| SCHEMBL7264963 | 0.73 | GRM6 (0.51) | GRM6SMN1; SMN2ALDH1A1GAAMAPT | |
| SCHEMBL5193911 | 0.73 | RAB9A (0.42) | CDC7DBF4TRPM8SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1321463-B1 | Thiazole derivatives and their use for the treatment or prevention of Flavivirus infections | VIROCHEM PHARMA INC (CA) | 2007-08-08 | — | — | EP | disclosed |
| EP-1321463-B1 | Thiazole derivatives and their use for the treatment or prevention of Flavivirus infections | VIROCHEM PHARMA INC (CA) | 2007-08-08 | — | — | EP | disclosed |
| US-6936629-B2 | Compounds and methods for the treatment or prevention of flavivirus infections | VIROCHEM PHARMA INC. (CA) | 2005-08-30 | — | — | US | disclosed |
| US-20030199503-A1 | Compounds and methods for the treatment of prevention of flavivirus infections | SHIRE BIOCHEM INC. (CA) | 2003-10-23 | — | — | US | disclosed |
| EP-1321463-A1 | Thiazole derivatives and their use for the treatment or prevention of Flavivirus infections | Shire Biochem Inc. (CA) | 2003-06-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030199503-A1 | Compounds and methods for the treatment of prevention of flavivirus infections | HAVCR2, ZC3HAV1, EIF2AK2 | CDC7 4724/4885DBF4 2982/4885TRPM8 2212/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.