Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 2/20 | 0.37 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.34 |
| ▸ | GOT1 | P17174 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 2/20 | 0.32 |
| ▸ | GRM5 | P41594 | 2/20 | 0.32 |
| ▸ | JAK2 | O60674 | 4/20 | 0.32 |
| ▸ | JAK1 | P23458 | 2/20 | 0.32 |
| ▸ | TYK2 | P29597 | 2/20 | 0.32 |
| ▸ | GCK | P35557 | 1/20 | 0.32 |
| ▸ | CDK4 | P11802 | 1/20 | 0.32 |
| ▸ | CCND1 | P24385 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | NAMPT | P43490 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2829922 | 0.82 | GRM5 (0.46) | LCKFFAR2GOT1BTKGRM5 | |
| SCHEMBL2826494 | 0.65 | ALDH1A1 (0.49) | LCKBTKGRM5JAK2JAK3 | |
| SCHEMBL20956876 | 0.62 | LCK (0.38) | LCKGOT1BTKJAK2JAK1 | |
| SCHEMBL15931763 | 0.62 | GOT1 (0.50) | FFAR2GOT1NAMPT | |
| SCHEMBL2833046 | 0.62 | NTRK1 (0.47) | GRM5 | |
| SCHEMBL20376364 | 0.62 | KDM4E (0.43) | GAACYP2C9 | |
| SCHEMBL14691520 | 0.61 | HIPK4 (0.48) | — | |
| SCHEMBL15348825 | 0.61 | GOT1 (0.52) | LCKFFAR2GOT1JAK2JAK1 | |
| SCHEMBL20606962 | 0.60 | FFAR2 (0.48) | LCKFFAR2GOT1JAK2JAK1 | |
| Trifluoroacetic Acid SCHEMBL28053522 | 0.60 | GOT1 (0.43) | LCKFFAR2GOT1JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-A1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-10-17 | — | — | EP | claimed |
| WO-2006074884-A1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-07-20 | — | — | WO | claimed |