Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 3/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 9/20 | 0.37 |
| ▸ | TGFBR2 | P37173 | 3/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.32 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.32 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.32 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23389579 | 0.83 | DGAT1 (0.38) | DGAT1TGFBR1TGFBR2MAPK14PDE10A | |
| SCHEMBL29796642 | 0.83 | DGAT1 (0.38) | DGAT1TGFBR1TGFBR2MAPK14PDE10A | |
| SCHEMBL30099428 | 0.81 | DGAT1 (0.41) | DGAT1TGFBR1TGFBR2PDE10A | |
| SCHEMBL29796654 | 0.80 | TGFBR1 (0.34) | DGAT1TGFBR1TGFBR2MAPK14 | |
| SCHEMBL30099363 | 0.80 | MTOR (0.36) | DGAT1TGFBR1TGFBR2MAPK14PDE10A | |
| SCHEMBL23389732 | 0.80 | TGFBR1 (0.34) | DGAT1TGFBR1TGFBR2MAPK14 | |
| SCHEMBL30099409 | 0.78 | DGAT1 (0.41) | DGAT1TGFBR1TGFBR2MAPK14PDE10A | |
| SCHEMBL23391895 | 0.78 | DGAT1 (0.37) | DGAT1TGFBR1PDE10A | |
| SCHEMBL29967610 | 0.78 | DGAT1 (0.37) | DGAT1TGFBR1PDE10A | |
| SCHEMBL23390009 | 0.78 | TGFBR1 (0.34) | DGAT1TGFBR1TGFBR2MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070275968-A1 | Substituted Biphenyl Derivative | SANKYO COMPANY, LIMITED (JP) | 2007-11-29 | — | — | US | disclosed |
| EP-1798229-A1 | SUBSTITUTED BIPHENYL DERIVATIVE | Sankyo Company, Limited (JP) | 2007-06-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070275968-A1 | Substituted Biphenyl Derivative | COL2A1, COL1A1, FGFR3 | DGAT1 3660/4885TGFBR1 40/4885TGFBR2 51/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.