Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 7/20 | 0.73 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | HTR2A | P28223 | 3/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5197976 | 0.99 | OPRL1 (0.73) | OPRL1OPRM1KMT2AALDH1A1MEN1 | |
| SCHEMBL5163716 | 0.84 | OPRL1 (1.00) | OPRL1OPRM1KMT2AALDH1A1MEN1 | |
| Hydrochloric Acid SCHEMBL5165408 | 0.83 | OPRL1 (1.00) | OPRL1OPRM1KMT2AALDH1A1MEN1 | |
| SCHEMBL2379623 | 0.82 | BCHE (0.55) | OPRL1OPRM1KMT2AMEN1BCHE | |
| Hydrochloric Acid SCHEMBL2380275 | 0.82 | BCHE (0.54) | OPRL1OPRM1KMT2AMEN1BCHE | |
| SCHEMBL5164738 | 0.79 | OPRL1 (0.78) | OPRL1OPRM1KMT2AALDH1A1MEN1 | |
| Hydrochloric Acid SCHEMBL5163420 | 0.78 | OPRL1 (0.78) | OPRL1OPRM1KMT2AALDH1A1MEN1 | |
| SCHEMBL5199686 | 0.78 | MC4R (0.47) | OPRL1OPRM1KMT2AMEN1HTR2A | |
| SCHEMBL5858607 | 0.78 | FPR2 (0.48) | OPRL1OPRM1KMT2AMEN1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6551542 | 0.78 | OPRM1 (0.49) | OPRL1OPRM1KMT2AALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1385825-B1 | SUBSTITUTED 2-PYRIDINE-CYCLOHEXANE-1,4-DIAMINE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-08-15 | — | — | EP | claimed |
| EP-1385825-B1 | SUBSTITUTED 2-PYRIDINE-CYCLOHEXANE-1,4-DIAMINE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-08-15 | — | — | EP | disclosed |
| US-6998409-B2 | Substituted 2-pyridine cyclohexane-1,4-diamine compounds | GRUENENTHAL GMBH (DE) | 2006-02-14 | — | — | US | disclosed |
| US-20040229872-A1 | Substituted cyclohexane-1,4-diamine compounds with anti-diarrhea and peripheral analgesic activity | GRUENENTHAL GMBH (DE) | 2004-11-18 | — | — | US | disclosed |
| US-20040147741-A1 | Substituted 2-pyridine cyclohexane-1,4-diamine compounds | GRUENENTHAL GMBH (DE) | 2004-07-29 | — | — | US | disclosed |
| EP-1385825-A1 | SUBSTITUTED 2-PYRIDINE-CYCLOHEXANE-1,4-DIAMINE DERIVATIVES | Grünenthal GmbH (DE) | 2004-02-04 | — | — | EP | disclosed |
| EP-1385493-A1 | SUBSTITUTED CYCLOHEXAN-1,4-DIAMINE DERIVATIVES WITH CONSTIPATING AND PERIPHERAL ANALGESIC PROPERTIES | Grünenthal GmbH (DE) | 2004-02-04 | — | — | EP | disclosed |
| WO-2002089783-A1 | SUBSTITUTED CYCLOHEXAN-1,4-DIAMINE DERIVATIVES WITH CONSTIPATING AND PERIPHERAL ANALGESIC PROPERTIES | Grünenthal GmbH (DE) | 2002-11-14 | — | — | WO | disclosed |
| WO-2002090330-A1 | SUBSTITUTED 2-PYRIDINE-CYCLOHEXANE-1,4-DIAMINE DERIVATIVES | Grünenthal GmbH (DE) | 2002-11-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040147741-A1 | Substituted 2-pyridine cyclohexane-1,4-diamine compounds | P2RX4, QDPR, DPYD | OPRL1 35/4885OPRM1 56/4885KMT2A 2212/4885 |
| US-20040229872-A1 | Substituted cyclohexane-1,4-diamine compounds with anti-diarrhea and peripheral analgesic activity | ARG1, CD2, PDCD1 | OPRL1 41/4885OPRM1 250/4885KMT2A 3549/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.