Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 8/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 6/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.38 |
| ▸ | KDR | P35968 | 4/20 | 0.38 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.37 |
| ▸ | PRKDC | P78527 | 1/20 | 0.37 |
| ▸ | SCD | O00767 | 1/20 | 0.36 |
| ▸ | FADS1 | O60427 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5198229 | 0.90 | PTGS2 (0.39) | PTGS2PTGS1GABRA2FAAHTGFBR1 | |
| SCHEMBL5199341 | 0.86 | TGFBR1 (0.44) | PTGS2TGFBR1MAPK14KDRRIPK2 | |
| SCHEMBL5198372 | 0.77 | PTGS2 (0.45) | PTGS2PTGS1GABRA2TGFBR1 | |
| SCHEMBL5199026 | 0.76 | TGFBR1 (0.42) | PTGS2PTGS1GABRA2FAAHTGFBR1 | |
| SCHEMBL5199436 | 0.76 | GABRA2 (0.42) | GABRA2TGFBR1MAPK14KDR | |
| SCHEMBL5199938 | 0.76 | TGFBR1 (0.41) | TGFBR1MAPK14KDRRIPK2 | |
| SCHEMBL5199610 | 0.76 | TGFBR1 (0.42) | PTGS2GABRA2TGFBR1MAPK14KDR | |
| SCHEMBL5199630 | 0.76 | TGFBR1 (0.42) | PTGS2GABRA2TGFBR1MAPK14KDR | |
| SCHEMBL5199855 | 0.74 | TGFBR1 (0.45) | GABRA2TGFBR1MAPK14KDRRIPK2 | |
| SCHEMBL5199678 | 0.74 | MAP2K4 (0.42) | TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070275968-A1 | Substituted Biphenyl Derivative | SANKYO COMPANY, LIMITED (JP) | 2007-11-29 | — | — | US | disclosed |
| EP-1798229-A1 | SUBSTITUTED BIPHENYL DERIVATIVE | Sankyo Company, Limited (JP) | 2007-06-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070275968-A1 | Substituted Biphenyl Derivative | COL2A1, COL1A1, FGFR3 | PTGS2 2062/4885PTGS1 1855/4885GABRA2 472/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.