Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | PLK1 | P53350 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.35 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4169306 | 0.88 | MAPT (0.48) | NPSR1HPGDRAB9AALDH1A1LMNA | |
| SCHEMBL4172471 | 0.82 | KDM4E (0.43) | MEN1KMT2AADRB2ADRB3MAPK1 | |
| SCHEMBL9055592 | 0.81 | CYP2C9 (0.54) | CYP2C9CYP2C19LMNAMAPT | |
| SCHEMBL3187016 | 0.80 | ALDH1A1 (0.43) | HPGDMEN1KMT2AADRB2ADRB3 | |
| SCHEMBL8727337 | 0.77 | TAAR1 (0.41) | ADRB2ADRB3 | |
| SCHEMBL8681272 | 0.75 | KMT2A (0.46) | KMT2APARP10ALDH1A1POLBMAPT | |
| SCHEMBL4167588 | 0.73 | FDPS (0.44) | MEN1KMT2AADRB2LMNAPOLB | |
| SCHEMBL4156218 | 0.73 | CHRNB2 (0.41) | ADRB2ADRB3MAPK1CYP2C9CYP2C19 | |
| SCHEMBL5198811 | 0.73 | PLK1 (0.45) | NPSR1HPGDPLK1KMT2APARP10 | |
| SCHEMBL1251493 | 0.71 | ADRB2 (0.33) | ADRB2ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1809299-A2 | PHOSPHONATE SUBSTITUTED KINASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2007-07-25 | — | — | EP | disclosed |
| WO-2006047507-A2 | PHOSPHONATE SUBSTITUTED KINASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2006-05-04 | — | — | WO | disclosed |