Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 3/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.38 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.38 |
| ▸ | TNF | P01375 | 1/20 | 0.37 |
| ▸ | IL6 | P05231 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8112257 | 0.81 | NFE2L2 (0.50) | IDO1NFE2L2TAAR1LMNA | |
| SCHEMBL1133197 | 0.75 | ALDH1A1 (0.41) | IDO1NFE2L2TAAR1LMNA | |
| SCHEMBL3721541 | 0.74 | NFKB1 (0.48) | NFKB1IDO1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL27947936 | 0.72 | NFKB1 (0.52) | NFKB1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL5199196 | 0.72 | TAAR1 (0.54) | IDO1TAAR1PTGS2MAOB | |
| SCHEMBL8397406 | 0.70 | TAAR1 (0.45) | IDO1NFE2L2TAAR1LMNA | |
| SCHEMBL5610552 | 0.69 | NFKB1 (0.44) | NFKB1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL11601066 | 0.69 | NFKB1 (0.44) | NFKB1IDO1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL27865982 | 0.69 | NFKB1 (0.49) | NFKB1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL5542863 | 0.69 | NFKB1 (0.44) | NFKB1IDO1GRIN2DGRIN3BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1814863-A1 | INDAZOLE SULPHONAMIDE DERIVATIVES | AstraZeneca AB (SE) | 2007-08-08 | — | — | EP | disclosed |
| WO-2006052190-A1 | INDAZOLE SULPHONAMIDE DERIVATIVES | ASTRAZENECA AB (SE) | 2006-05-18 | — | — | WO | disclosed |