Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 4/20 | 0.79 |
| ▸ | CES1 | P23141 | 2/20 | 0.79 |
| ▸ | KIF11 | P52732 | 1/20 | 0.54 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.52 |
| ▸ | GSK3B | P49841 | 2/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | LTA4H | P09960 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.47 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.47 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.47 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.46 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.46 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.46 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3172262 | 0.89 | CES2 (1.00) | CES2CES1SRD5A2GSK3BPTPN1 | |
| SCHEMBL4030893 | 0.82 | CES2 (0.77) | CES2CES1SRD5A2MEN1HPGD | |
| SCHEMBL2783342 | 0.82 | NAPRT (0.65) | CES2CES1MEN1HPGDKMT2A | |
| SCHEMBL5197425 | 0.82 | KIF11 (0.55) | CES2CES1KIF11SRD5A2MEN1 | |
| SCHEMBL2834217 | 0.81 | CES2 (0.83) | CES2CES1KIF11SRD5A2GSK3B | |
| SCHEMBL20010796 | 0.81 | CES2 (0.83) | CES2CES1SRD5A2GSK3BPTPN1 | |
| SCHEMBL4749048 | 0.81 | CES2 (0.56) | CES2CES1KIF11SRD5A2ALDH1A1 | |
| SCHEMBL3053668 | 0.78 | LTA4H (0.76) | CES2CES1MEN1KMT2ALTA4H | |
| SCHEMBL3058646 | 0.78 | CES2 (0.78) | CES2CES1SRD5A2GSK3BPTPN1 | |
| SCHEMBL3753543 | 0.78 | CES2 (0.76) | CES2CES1KIF11SRD5A2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1846389-A1 | IMIDAZOLE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2007-10-24 | — | — | EP | disclosed |
| WO-2006082002-A1 | IMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-08-10 | — | — | WO | disclosed |
| US-20060173048-A1 | Imidazole derivatives | F. HOFFMAN-LA ROCHE AG (CH) | 2006-08-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060173048-A1 | Imidazole derivatives | GRM2, GRM1, GRIN2C | CES2 730/4885CES1 1786/4885KIF11 3495/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.