Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.40 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5310120 | 0.83 | GPR119 (0.44) | ALDH1A1MAPTBRD4GPR119CHRM2 | |
| SCHEMBL3941601 | 0.82 | OPRM1 (0.51) | BRD4PRMT5WDR77DRD2L3MBTL1 | |
| SCHEMBL4900251 | 0.81 | GPR119 (0.49) | GPR119PRMT5WDR77 | |
| SCHEMBL5199608 | 0.81 | GPR119 (0.49) | ALDH1A1BRD4GPR119CHRM2CHRM1 | |
| SCHEMBL3940080 | 0.76 | OPRM1 (0.46) | PRMT5WDR77DRD2 | |
| SCHEMBL5196493 | 0.76 | GPR119 (0.45) | ALDH1A1MAPTGPR119CHRM2CHRM1 | |
| SCHEMBL5197000 | 0.74 | DPP4 (0.43) | MAPTGPR119PRMT5WDR77CHRM2 | |
| SCHEMBL5197149 | 0.74 | GPR119 (0.41) | MAPTGPR119PRMT5WDR77CHRM2 | |
| SCHEMBL5199217 | 0.73 | CHRM2 (0.45) | ALDH1A1GPR119CHRM2CHRM1KDM4E | |
| SCHEMBL5228645 | 0.73 | CHRM2 (0.48) | MAPTGPR119CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1814873-A2 | 5-SULFONYL-1-PIPERIDINYL SUBSTITUTED INDOLE DERIVATIVES AS 5-HT6 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CNS DISORDERS | GLAXO GROUP LIMITED (GB) | 2007-08-08 | — | — | EP | disclosed |
| WO-2006038006-A2 | 5-SULFONYL-1-PIPERIDINYL SUBSTITUTED INDOLE DERIVATIVES AS 5-HT6 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CNS DISORDERS | GLAXO GROUP LIMITED (GB) | 2006-04-13 | — | — | WO | disclosed |