Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 6/20 | 0.39 |
| ▸ | MMP7 | P09237 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | MMP14 | P50281 | 1/20 | 0.39 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 3/20 | 0.35 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ANPEP | P15144 | 1/20 | 0.34 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.34 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.34 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6130847 | 0.86 | ADAMTS4 (0.40) | MMP2MMP7MMP9MMP8MMP13 | |
| SCHEMBL2350989 | 0.82 | CPB2 (0.42) | MMP2MMP7MMP9MMP8MMP13 | |
| SCHEMBL2351855 | 0.82 | CPB2 (0.42) | MMP2MMP7MMP9MMP8MMP13 | |
| SCHEMBL6130893 | 0.82 | CPB2 (0.42) | MMP2MMP7MMP9MMP8MMP13 | |
| SCHEMBL2349012 | 0.82 | CPB2 (0.42) | MMP2MMP7MMP9MMP8MMP13 | |
| SCHEMBL2357292 | 0.82 | CPB2 (0.42) | MMP2MMP7MMP9MMP8MMP13 | |
| SCHEMBL2356327 | 0.82 | CPB2 (0.42) | MMP2MMP7MMP9MMP8MMP13 | |
| SCHEMBL6130890 | 0.81 | ALDH1A1 (0.43) | MMP2MMP7MMP9MMP8MMP13 | |
| SCHEMBL2353899 | 0.79 | CPB2 (0.41) | MMP2MMP7MMP9MMP8MMP13 | |
| Trifluoroacetic Acid SCHEMBL4713282 | 0.78 | CPB2 (0.39) | MMP2MMP7MMP9MMP8MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1817041-A2 | TAFI INHIBITORS AND THEIR USE TO TREAT PULMONARY FIBROSIS | Bayer Schering Pharma Aktiengesellschaft (DE) | 2007-08-15 | — | — | EP | disclosed |
| WO-2006041808-A2 | TAFI INHIBITORS AND THEIR USE TO TREAT PULMONARY FIBROSIS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2006-04-20 | — | — | WO | disclosed |