Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP7 | P09237 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | MMP14 | P50281 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | CFD | P00746 | 1/20 | 0.33 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | ANPEP | P15144 | 1/20 | 0.32 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5199800 | 0.86 | MMP2 (0.39) | ADAMTS4MMP2MMP7MMP9MMP8 | |
| SCHEMBL6130890 | 0.85 | ALDH1A1 (0.43) | ADAMTS4MMP2MMP7MMP9MMP8 | |
| SCHEMBL2352197 | 0.79 | ADAMTS4 (0.42) | ADAMTS4MMP2MMP7MMP9MMP8 | |
| SCHEMBL2353236 | 0.69 | MMP2 (0.49) | ADAMTS4MMP2MMP7MMP9MMP8 | |
| SCHEMBL2354741 | 0.69 | SLC1A3 (0.41) | ADAMTS4MMP2MMP7MMP9MMP8 | |
| SCHEMBL23752597 | 0.69 | MMP2 (0.49) | ADAMTS4MMP2MMP7MMP9MMP8 | |
| SCHEMBL2353188 | 0.68 | ADAMTS4 (0.40) | ADAMTS4MMP2MMP7MMP9MMP8 | |
| SCHEMBL23752492 | 0.67 | ANPEP (0.41) | ADAMTS4MMP2MMP7MMP9MMP8 | |
| SCHEMBL23752491 | 0.67 | ANPEP (0.41) | ADAMTS4MMP2MMP7MMP9MMP8 | |
| SCHEMBL2353264 | 0.67 | ANPEP (0.41) | ADAMTS4MMP2MMP7MMP9MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1497300-A2 | PLASMA CARBOXYPEPTIDASE B INHIBITORS | Schering Aktiengesellschaft (DE) | 2005-01-19 | — | — | EP | disclosed |
| WO-2003080631-A2 | PLASMA CARBOXYPEPTIDASE B INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 2003-10-02 | — | — | WO | disclosed |