Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.39 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.39 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP7 | P09237 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | MMP14 | P50281 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6130847 | 0.85 | ADAMTS4 (0.40) | ALDH1A1ADAMTS4MMP2MMP7MMP9 | |
| SCHEMBL2352464 | 0.82 | ALDH1A1 (0.43) | ALDH1A1PTGER3MEN1KMT2AMAPT | |
| SCHEMBL5199800 | 0.81 | MMP2 (0.39) | ADAMTS4MMP2MMP7MMP9MMP8 | |
| SCHEMBL23752597 | 0.67 | MMP2 (0.49) | ALDH1A1ADAMTS4MMP2MMP7MMP9 | |
| SCHEMBL2353236 | 0.67 | MMP2 (0.49) | ALDH1A1ADAMTS4MMP2MMP7MMP9 | |
| SCHEMBL2352197 | 0.66 | ADAMTS4 (0.42) | ADAMTS4MMP2MMP7MMP9MMP8 | |
| SCHEMBL2354151 | 0.65 | ADAMTS4 (0.58) | ADAMTS4MMP2MMP7MMP9MMP8 | |
| SCHEMBL2353188 | 0.65 | ADAMTS4 (0.40) | ADAMTS4MMP2MMP7MMP9MMP8 | |
| SCHEMBL23752492 | 0.64 | ANPEP (0.41) | ALDH1A1ADAMTS4MMP2MMP7MMP9 | |
| SCHEMBL23752491 | 0.64 | ANPEP (0.41) | ALDH1A1ADAMTS4MMP2MMP7MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1497300-A2 | PLASMA CARBOXYPEPTIDASE B INHIBITORS | Schering Aktiengesellschaft (DE) | 2005-01-19 | — | — | EP | disclosed |
| WO-2003080631-A2 | PLASMA CARBOXYPEPTIDASE B INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 2003-10-02 | — | — | WO | disclosed |