Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 2/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | SCN4A | P35499 | 2/20 | 0.31 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.31 |
| ▸ | PNMT | P11086 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
| ▸ | HTR2B | P41595 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2769421 | 0.71 | HTR2A (0.50) | PTGS2PNMTHTR2AHIF1AHSD17B10 | |
| SCHEMBL28948705 | 0.71 | PTGS2 (0.42) | PTGS2HTR2ACYP1A2CYP2D6CYP2C9 | |
| SCHEMBL19399649 | 0.71 | IDO1 (0.47) | CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL23391560 | 0.71 | IDO1 (0.47) | CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL2769756 | 0.70 | MEN1 (0.40) | PTGS2CYP1A2CYP2D6CYP2C19MEN1 | |
| SCHEMBL5200343 | 0.69 | HTR2A (0.34) | F2PTGS2HTR2ACYP1A2CYP2D6 | |
| SCHEMBL4153146 | 0.68 | TAAR1 (0.47) | HTR2ACYP1A2CYP2D6L3MBTL1HTR2C | |
| SCHEMBL13576841 | 0.68 | ACLY (0.47) | CYP1A2CYP2C19L3MBTL1MEN1KMT2A | |
| SCHEMBL15352016 | 0.68 | L3MBTL1 (0.41) | PTGS2HTR2ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL4339469 | 0.68 | L3MBTL1 (0.41) | PTGS2HTR2ACYP1A2CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753739-A1 | IMIDAZOL-2-ONE COMPOUNDS USEFUL IN THE TREATMENT OF VARIOUS DISORDERS | GLAXO GROUP LIMITED (GB) | 2007-02-21 | — | — | EP | disclosed |
| WO-2005121122-A1 | IMIDAZOL-2-ONE COMPOUNDS USEFUL IN THE TREATMENT OF VARIOUS DISORDERS | GLAXO GROUP LIMITED (GB) | 2005-12-22 | — | — | WO | disclosed |