SCHEMBL5200440

SCHEMBL5200440

CC(c1ccc(Cl)cc1)C(CNC(=O)C1(c2cccnc2)CCCC1)c1ccccc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.48
ITGA4 P13612 2/20 0.43
ITGB7 P26010 2/20 0.43
CNR1 P21554 1/20 0.41
IDO1 P14902 1/20 0.41
KCNA5 P22460 4/20 0.41
TRPA1 O75762 4/20 0.40
CYP3A4 P08684 1/20 0.40
CYP2C8 P10632 1/20 0.40
CYP2D6 P10635 1/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40
KCNH2 Q12809 1/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
LMNA P02545 2/20 0.40
P2RX7 Q99572 2/20 0.40
HTT P42858 1/20 0.40
HDAC4 P56524 1/20 0.40
TP53 P04637 1/20 0.40
NPSR1 Q6W5P4 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5202615 0.96 ALDH1A1 (0.43) ALDH1A1ITGA4ITGB7CNR1KCNA5
SCHEMBL5200569 0.86 TRPA1 (0.46) ALDH1A1TRPA1CYP3A4CYP2C8CYP2D6
SCHEMBL5203380 0.85 HDAC4 (0.42) CNR1IDO1TRPA1CYP3A4CYP2C8
SCHEMBL4823270 0.81 CNR1 (0.58) ALDH1A1ITGA4ITGB7CNR1
SCHEMBL5264331 0.80 LMNA (0.52) CNR1KCNA5CYP2C9CYP2C19SMN1; SMN2
SCHEMBL4831230 0.79 CNR1 (0.53) ALDH1A1ITGA4ITGB7CNR1
SCHEMBL14064694 0.79 CNR1 (0.53) ALDH1A1ITGA4ITGB7CNR1
SCHEMBL4827955 0.77 CNR1 (0.60) ITGA4ITGB7CNR1
Trifluoroacetic Acid SCHEMBL4831441 0.76 CNR1 (0.53) ALDH1A1ITGA4ITGB7CNR1
SCHEMBL5205537 0.76 HDAC4 (0.42) ALDH1A1TRPA1SMN1; SMN2LMNAP2RX7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1490043-A4 SPIROCYCLIC AMIDES AS CANNABINOID RECEPTOR MODULATORS MERCK & CO INC (US) 2007-05-30 EP disclosed
EP-1490043-A2 SPIROCYCLIC AMIDES AS CANNABINOID RECEPTOR MODULATORS Merck & Co., Inc. (US) 2004-12-29 EP disclosed
WO-2003082190-A2 SPIROCYCLIC AMIDES AS CANNABINOID RECEPTOR MODULATORS MERCK & CO., INC. (US) 2003-10-09 WO disclosed