Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CYP27B1 | O15528 | 2/20 | 0.47 |
| ▸ | CYP24A1 | Q07973 | 2/20 | 0.47 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5262488 | 0.89 | SLC6A9 (0.55) | SLC6A9EPHX2SLC6A5CYP27B1CYP24A1 | |
| SCHEMBL5262774 | 0.88 | SLC6A9 (0.54) | SLC6A9SLC6A5GPR139MEN1KMT2A | |
| SCHEMBL5262392 | 0.83 | SLC6A9 (0.53) | TSHRSLC6A9EPHX2CYP27B1CYP24A1 | |
| SCHEMBL5266049 | 0.82 | RAB9A (0.60) | LMNATSHRSLC6A9SLC6A5MAPT | |
| SCHEMBL5202615 | 0.81 | ALDH1A1 (0.43) | LMNATSHRCNR1KCNA5TP53 | |
| SCHEMBL5260012 | 0.81 | UTS2R (0.53) | SLC6A9SLC6A5MAPTCYP27B1CYP24A1 | |
| SCHEMBL5260864 | 0.81 | SLC6A9 (0.46) | LMNATSHRSLC6A9CYP2C9SLC6A5 | |
| SCHEMBL4691697 | 0.81 | CNR1 (0.67) | CYP2C9CYP2C19CNR1 | |
| SCHEMBL5200440 | 0.80 | ALDH1A1 (0.48) | LMNACYP2C9CYP2C19CNR1SMN1; SMN2 | |
| SCHEMBL5263576 | 0.80 | RAB9A (0.46) | LMNATSHRSLC6A9MAPTGPR139 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1494997-A4 | SUBSTITUTED ARYL AMIDES | MERCK & CO INC (US) | 2007-04-11 | — | — | EP | claimed |
| JP-2005527586-A | — | — | 2005-09-15 | — | — | JP | claimed |
| EP-1494997-A1 | SUBSTITUTED ARYL AMIDES | Merck & Co., Inc. (US) | 2005-01-12 | — | — | EP | claimed |
| WO-2003087037-A1 | SUBSTITUTED ARYL AMIDES | MERCK & CO., INC. (US) | 2003-10-23 | — | — | WO | claimed |
| EP-1494997-A4 | SUBSTITUTED ARYL AMIDES | MERCK & CO INC (US) | 2007-04-11 | — | — | EP | disclosed |
| EP-1494997-A1 | SUBSTITUTED ARYL AMIDES | Merck & Co., Inc. (US) | 2005-01-12 | — | — | EP | disclosed |
| WO-2003087037-A1 | SUBSTITUTED ARYL AMIDES | MERCK & CO., INC. (US) | 2003-10-23 | — | — | WO | disclosed |