Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 4/20 | 0.42 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.41 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 2/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5200569 | 0.88 | TRPA1 (0.46) | HDAC4SMN1; SMN2KCNH2HTTTRPA1 | |
| SCHEMBL5200440 | 0.85 | ALDH1A1 (0.48) | HDAC4SMN1; SMN2KCNH2IDO1HTT | |
| SCHEMBL4829758 | 0.80 | CNR1 (0.55) | CNR1CNR2 | |
| SCHEMBL5202615 | 0.80 | ALDH1A1 (0.43) | TRPA1LMNATP53CNR1TSHR | |
| SCHEMBL5205537 | 0.80 | HDAC4 (0.42) | HDAC4SMN1; SMN2TRPA1NPSR1LMNA | |
| SCHEMBL5202867 | 0.79 | CNR1 (0.45) | HDAC4TRPA1CNR1CNR2 | |
| SCHEMBL5201399 | 0.78 | TRPA1 (0.46) | HDAC4TRPA1CNR1CNR2 | |
| SCHEMBL5201238 | 0.77 | ITGB1 (0.45) | SMN1; SMN2CNR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5203142 | 0.77 | ALDH1A1 (0.48) | HDAC4SMN1; SMN2TRPA1CNR1CNR2 | |
| SCHEMBL5202986 | 0.77 | KMT2A (0.40) | HDAC4SMN1; SMN2KCNH2LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490043-A4 | SPIROCYCLIC AMIDES AS CANNABINOID RECEPTOR MODULATORS | MERCK & CO INC (US) | 2007-05-30 | — | — | EP | claimed |
| EP-1490043-A2 | SPIROCYCLIC AMIDES AS CANNABINOID RECEPTOR MODULATORS | Merck & Co., Inc. (US) | 2004-12-29 | — | — | EP | claimed |
| WO-2003082190-A2 | SPIROCYCLIC AMIDES AS CANNABINOID RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2003-10-09 | — | — | WO | claimed |