Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.52 |
| ▸ | HTR1A | P08908 | 6/20 | 0.52 |
| ▸ | HTR7 | P34969 | 6/20 | 0.52 |
| ▸ | DRD3 | P35462 | 6/20 | 0.52 |
| ▸ | HTR2B | P41595 | 6/20 | 0.52 |
| ▸ | HTR2A | P28223 | 5/20 | 0.52 |
| ▸ | HRH1 | P35367 | 5/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.52 |
| ▸ | CASP1 | P29466 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.46 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5200925 | 0.91 | HTR1A (0.55) | DRD2HTR1AHTR7DRD3HTR2B | |
| SCHEMBL6953088 | 0.87 | ABCG2 (0.52) | KDM4EALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL2857290 | 0.78 | ALDH1A1 (0.62) | DRD3KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL6959055 | 0.77 | KMT2A (0.57) | DRD2DRD3KDM4EALDH1A1MEN1 | |
| SCHEMBL5200960 | 0.76 | ALDH1A1 (0.49) | KDM4EALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL6953945 | 0.75 | ALDH1A1 (0.49) | KDM4EALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL6951470 | 0.74 | ALDH1A1 (0.48) | KDM4EALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL7233635 | 0.73 | ADORA1 (0.46) | KDM4EALDH1A1POLBGAAMEN1 | |
| SCHEMBL10938419 | 0.71 | HDAC10 (0.55) | KDM4EALDH1A1POLBMEN1KMT2A | |
| SCHEMBL3478431 | 0.71 | ALDH1A1 (0.59) | DRD2HTR1AHTR7DRD3HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1351950-B1 | ISOQUINOLINYL AROYL PYRROLE COMPOUNDS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | ORTHO MCNEIL PHARM INC (US) | 2007-08-08 | — | — | EP | claimed |
| US-6492387-B2 | ADMINISTERED AS AN ANTICONVULSANT AGENT, ANTIEPILEPTIC AGENT, NEUROPROTECTIVE AGENT, MUSCLE RELAXANT AGENT AND AGENT FOR THE TREATMENT OF NEUROPATHIC PAIN. | ORTHO-MCNEIL PHARAMACEUTICAL, INC. | 2002-12-10 | — | — | US | claimed |
| US-20020128286-A1 | Isoindolyl and isoquinolinyl aroyl pyrrole compounds | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2002-09-12 | — | — | US | claimed |
| EP-1351950-B1 | ISOQUINOLINYL AROYL PYRROLE COMPOUNDS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | ORTHO MCNEIL PHARM INC (US) | 2007-08-08 | — | — | EP | disclosed |
| US-6492387-B2 | ADMINISTERED AS AN ANTICONVULSANT AGENT, ANTIEPILEPTIC AGENT, NEUROPROTECTIVE AGENT, MUSCLE RELAXANT AGENT AND AGENT FOR THE TREATMENT OF NEUROPATHIC PAIN. | ORTHO-MCNEIL PHARAMACEUTICAL, INC. | 2002-12-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020128286-A1 | Isoindolyl and isoquinolinyl aroyl pyrrole compounds | QPCT, INA, OPRK1 | DRD2 61/4885HTR1A 637/4885HTR7 574/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.