Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2857290 | 0.90 | ALDH1A1 (0.62) | ALDH1A1KMT2AMAPTMEN1KDM4E | |
| SCHEMBL6959055 | 0.89 | KMT2A (0.57) | ALDH1A1KMT2AMAPTMEN1KDM4E | |
| SCHEMBL6953088 | 0.89 | ABCG2 (0.52) | ALDH1A1KMT2AMAPTMEN1KDM4E | |
| SCHEMBL6953945 | 0.86 | ALDH1A1 (0.49) | ALDH1A1KMT2AMAPTMEN1KDM4E | |
| SCHEMBL6951470 | 0.85 | ALDH1A1 (0.48) | ALDH1A1KMT2AMAPTMEN1KDM4E | |
| SCHEMBL5200481 | 0.76 | DRD2 (0.52) | ALDH1A1KMT2AMAPTMEN1KDM4E | |
| SCHEMBL5200925 | 0.75 | HTR1A (0.55) | ALDH1A1KMT2AMAPTMEN1KDM4E | |
| SCHEMBL3051805 | 0.72 | DHCR7 (0.62) | ALDH1A1KMT2AMAPTMEN1KDM4E | |
| SCHEMBL5278414 | 0.72 | USP4 (0.46) | ALDH1A1KMT2AMAPTMEN1NPSR1 | |
| Bromide SCHEMBL8790411 | 0.70 | ABCB1 (0.62) | ALDH1A1KMT2AMAPTMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1351950-A2 | ISOINDOLYL AND ISOQUINOLINYL AROYL PYRROLE COMPOUNDS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | Ortho-McNeil Pharmaceutical, Inc. (US) | 2003-10-15 | — | — | EP | claimed |
| US-6492387-B2 | ADMINISTERED AS AN ANTICONVULSANT AGENT, ANTIEPILEPTIC AGENT, NEUROPROTECTIVE AGENT, MUSCLE RELAXANT AGENT AND AGENT FOR THE TREATMENT OF NEUROPATHIC PAIN. | ORTHO-MCNEIL PHARAMACEUTICAL, INC. | 2002-12-10 | — | — | US | claimed |
| US-20020128286-A1 | Isoindolyl and isoquinolinyl aroyl pyrrole compounds | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2002-09-12 | — | — | US | claimed |
| WO-2002057253-A2 | ISOINDOLYL AND ISOQUINOLINYL AROYL PYRROLE COMPOUNDS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2002-07-25 | — | — | WO | claimed |
| EP-1351950-B1 | ISOQUINOLINYL AROYL PYRROLE COMPOUNDS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | ORTHO MCNEIL PHARM INC (US) | 2007-08-08 | — | — | EP | disclosed |
| EP-1351950-A2 | ISOINDOLYL AND ISOQUINOLINYL AROYL PYRROLE COMPOUNDS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | Ortho-McNeil Pharmaceutical, Inc. (US) | 2003-10-15 | — | — | EP | disclosed |
| US-6492387-B2 | ADMINISTERED AS AN ANTICONVULSANT AGENT, ANTIEPILEPTIC AGENT, NEUROPROTECTIVE AGENT, MUSCLE RELAXANT AGENT AND AGENT FOR THE TREATMENT OF NEUROPATHIC PAIN. | ORTHO-MCNEIL PHARAMACEUTICAL, INC. | 2002-12-10 | — | — | US | disclosed |
| US-20020128286-A1 | Isoindolyl and isoquinolinyl aroyl pyrrole compounds | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2002-09-12 | — | — | US | disclosed |
| WO-2002057253-A2 | ISOINDOLYL AND ISOQUINOLINYL AROYL PYRROLE COMPOUNDS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2002-07-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020128286-A1 | Isoindolyl and isoquinolinyl aroyl pyrrole compounds | QPCT, INA, OPRK1 | ALDH1A1 2152/4885KMT2A 3426/4885MAPT 368/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.