Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.50 |
| ▸ | DRD3 | P35462 | 2/20 | 0.50 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2857290 | 0.91 | ALDH1A1 (0.62) | KMT2AALDH1A1MAPTMEN1LMNA | |
| SCHEMBL6953088 | 0.90 | ABCG2 (0.52) | KMT2AATMALDH1A1MAPTMEN1 | |
| SCHEMBL5200960 | 0.89 | ALDH1A1 (0.49) | KMT2AATMALDH1A1MAPTMEN1 | |
| SCHEMBL6953945 | 0.88 | ALDH1A1 (0.49) | KMT2AATMALDH1A1MAPTMEN1 | |
| SCHEMBL6951470 | 0.87 | ALDH1A1 (0.48) | KMT2AATMALDH1A1MAPTMEN1 | |
| SCHEMBL5200925 | 0.86 | HTR1A (0.55) | KMT2AALDH1A1MAPTMEN1KDM4E | |
| SCHEMBL5200481 | 0.77 | DRD2 (0.52) | KMT2AALDH1A1MAPTMEN1KDM4E | |
| SCHEMBL7650883 | 0.77 | KMT2A (0.69) | KMT2AATMALDH1A1MAPTMEN1 | |
| SCHEMBL3051805 | 0.73 | DHCR7 (0.62) | KMT2AALDH1A1MAPTMEN1LMNA | |
| Bromide SCHEMBL8790411 | 0.72 | ABCB1 (0.62) | KMT2AATMALDH1A1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1351950-A2 | ISOINDOLYL AND ISOQUINOLINYL AROYL PYRROLE COMPOUNDS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | Ortho-McNeil Pharmaceutical, Inc. (US) | 2003-10-15 | — | — | EP | claimed |
| US-6492387-B2 | ADMINISTERED AS AN ANTICONVULSANT AGENT, ANTIEPILEPTIC AGENT, NEUROPROTECTIVE AGENT, MUSCLE RELAXANT AGENT AND AGENT FOR THE TREATMENT OF NEUROPATHIC PAIN. | ORTHO-MCNEIL PHARAMACEUTICAL, INC. | 2002-12-10 | — | — | US | claimed |
| US-20020128286-A1 | Isoindolyl and isoquinolinyl aroyl pyrrole compounds | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2002-09-12 | — | — | US | claimed |
| WO-2002057253-A2 | ISOINDOLYL AND ISOQUINOLINYL AROYL PYRROLE COMPOUNDS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2002-07-25 | — | — | WO | claimed |
| EP-1351950-A2 | ISOINDOLYL AND ISOQUINOLINYL AROYL PYRROLE COMPOUNDS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | Ortho-McNeil Pharmaceutical, Inc. (US) | 2003-10-15 | — | — | EP | disclosed |
| US-6492387-B2 | ADMINISTERED AS AN ANTICONVULSANT AGENT, ANTIEPILEPTIC AGENT, NEUROPROTECTIVE AGENT, MUSCLE RELAXANT AGENT AND AGENT FOR THE TREATMENT OF NEUROPATHIC PAIN. | ORTHO-MCNEIL PHARAMACEUTICAL, INC. | 2002-12-10 | — | — | US | disclosed |
| WO-2002057253-A2 | ISOINDOLYL AND ISOQUINOLINYL AROYL PYRROLE COMPOUNDS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2002-07-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020128286-A1 | Isoindolyl and isoquinolinyl aroyl pyrrole compounds | QPCT, INA, OPRK1 | KMT2A 3426/4885ATM 2166/4885ALDH1A1 2152/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.