Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5203052 | 0.79 | KDM4E (0.37) | KDM4ELMNAMAPTALDH1A1HSD17B10 | |
| SCHEMBL5201408 | 0.74 | TXNRD1 (0.45) | KDM4EMAPTALDH1A1 | |
| SCHEMBL8951994 | 0.74 | KDM4C (0.41) | KDM4ELMNAALDH1A1 | |
| SCHEMBL4822393 | 0.73 | KDM4E (0.42) | KDM4EMAPTALDH1A1HSD17B10 | |
| SCHEMBL9214485 | 0.70 | LMNA (0.43) | LMNAALDH1A1 | |
| SCHEMBL14221251 | 0.69 | PARP1 (0.49) | KDM4EMAPTALDH1A1HSD17B10 | |
| SCHEMBL1552386 | 0.68 | KMT2A (0.32) | KDM4ELMNAMAPTALDH1A1HSD17B10 | |
| SCHEMBL10749320 | 0.68 | KDM4E (0.47) | KDM4ELMNAMAPTALDH1A1HSD17B10 | |
| SCHEMBL7754586 | 0.64 | MAPT (0.48) | KDM4ELMNAMAPTALDH1A1HSD17B10 | |
| SCHEMBL1954453 | 0.64 | ALDH1A1 (0.52) | KDM4ELMNAMAPTALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1492771-B1 | QUINOLINE AND ISOQUINOLINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND USE THEREOF AS ANTI-INFLAMMATORY AGENTS | SCHERING AG (DE) | 2007-02-28 | — | — | EP | disclosed |
| EP-1492771-A1 | QUINOLINE AND ISOQUINOLINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND USE THEREOF AS ANTI-INFLAMMATORY AGENTS | SCHERING AKTIENGESELLSCHAFT (DE) | 2005-01-05 | — | — | EP | disclosed |
| WO-2003082827-A1 | QUINOLINE AND ISOQUINOLINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND USE THEREOF AS ANTI-INFLAMMATORY AGENTS | SCHERING AKTIENGESELLSCHAFT (DE) | 2003-10-09 | — | — | WO | disclosed |