Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 3/20 | 0.36 |
| ▸ | DRD3 | P35462 | 3/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD5 | P21918 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HTR1D | P28221 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5781349 | 0.84 | MAPT (0.37) | ALDH1A1TDP1SMN1; SMN2DRD2DRD3 | |
| SCHEMBL18620363 | 0.82 | PDE4A (0.36) | ALDH1A1TDP1DRD2DRD3PDE4A | |
| SCHEMBL16958356 | 0.78 | ALDH1A1 (0.58) | ALDH1A1TDP1TSHRTP53HPGD | |
| SCHEMBL6934553 | 0.78 | MAPT (0.43) | ALDH1A1DRD2DRD3DRD1DRD4 | |
| SCHEMBL30665126 | 0.77 | DRD2 (0.42) | ALDH1A1TSHRHPGDSMN1; SMN2RAB9A | |
| SCHEMBL2984151 | 0.77 | DRD2 (0.42) | ALDH1A1TSHRHPGDSMN1; SMN2RAB9A | |
| Hydrogen Sulfide SCHEMBL27838727 | 0.76 | MAPT (0.42) | ALDH1A1DRD2DRD3DRD1DRD4 | |
| Hydrogen Sulfide SCHEMBL28795253 | 0.76 | DRD2 (0.41) | ALDH1A1TSHRHPGDSMN1; SMN2RAB9A | |
| SCHEMBL1616513 | 0.76 | ALDH1A1 (0.69) | ALDH1A1TDP1TSHRTP53HPGD | |
| SCHEMBL19948194 | 0.75 | DRD2 (0.41) | DRD2DRD3DRD1DRD4DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1401813-B1 | NEW INDOLE DERIVATIVES WITH 5-HT6 RECEPTOR AFFINITY | HOFFMANN LA ROCHE (CH) | 2007-02-07 | — | — | EP | disclosed |
| EP-1401813-B1 | NEW INDOLE DERIVATIVES WITH 5-HT6 RECEPTOR AFFINITY | HOFFMANN LA ROCHE (CH) | 2007-02-07 | — | — | EP | disclosed |
| CN-1257892-C | New indole derivatives with 5-HT6 receptor affinity | HOFFMANN LA ROCHE (CH) | 2006-05-31 | — | — | CN | disclosed |
| US-20050171118-A1 | New indole derivatives with 5-HT6 receptor affinity | BEARD COLIN C (US) | 2005-08-04 | — | — | US | disclosed |
| US-20040248902-A1 | New indole derivatives with 5-HT6 receptor affinity | BEARD COLIN CHARLES (US) | 2004-12-09 | — | — | US | disclosed |
| CN-1527816-A | Novel indole derivatives having 5-HT 6 receptor affinity | - | 2004-09-08 | — | — | CN | disclosed |
| US-6787535-B2 | CENTRAL NERVOUS SYSTEM DISORDERS; PARKINSON'S DISEASE, HUNTINGTON'S DISEASE; PSYCOLOGICAL DISORDERS | SYNTEX (U.S.A.) LLC | 2004-09-07 | — | — | US | disclosed |
| EP-1401813-A1 | NEW INDOLE DERIVATIVES WITH 5-HT6 RECEPTOR AFFINITY | F. Hoffman-la Roche AG (CH) | 2004-03-31 | — | — | EP | disclosed |
| US-20030073700-A1 | New indole derivatives with 5HT6 receptor affinity | SYNTEX (U.S.A.) LLC, NAME CHANGE TO ROCHE PALO ALTO LLC | 2003-04-17 | — | — | US | disclosed |
| WO-2002098857-A1 | NEW INDOLE DERIVATIVES WITH 5-HT6 RECEPTOR AFFINITY | F. HOFFMANN-LA ROCHE AG (CH) | 2002-12-12 | — | — | WO | disclosed |
| EP-0530335-B1 | DIPHOSPHONIC ACID DERIVATES AS INTERMEDIATES FOR THE PRODUCTION OF DIPHOSPHINE LIGANDS | HOFFMANN LA ROCHE (CH) | 1996-08-14 | — | — | EP | disclosed |
| EP-0530335-A1 | DIPHOSPHONIC ACID DERIVATES AS INTERMEDIATES FOR THE PRODUCTION OF DIPHOSPHINE LIGANDS. | HOFFMANN LA ROCHE (CH) | 1993-03-10 | — | — | EP | disclosed |
| WO-1992016535-A1 | DIPHOSPHONIC ACID DERIVATES AS INTERMEDIATES FOR THE PRODUCTION OF DIPHOSPHINE LIGANDS | F.HOFFMANN-LA ROCHE AG (CH) | 1992-10-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040248902-A1 | New indole derivatives with 5-HT6 receptor affinity | HTR6, HTR5A, HTR7 | ALDH1A1 1833/4885TDP1 3604/4885TSHR 182/4885 |
| US-20050171118-A1 | New indole derivatives with 5-HT6 receptor affinity | HTR6, HTR5A, HTR7 | ALDH1A1 2354/4885TDP1 3797/4885TSHR 137/4885 |
| US-20030073700-A1 | New indole derivatives with 5HT6 receptor affinity | HTR6, HTR5A, HTR7 | ALDH1A1 1394/4885TDP1 3335/4885TSHR 176/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.