Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 4/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.47 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.47 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5204050 | 0.82 | ADRA1A (0.42) | ADRA1AADRA2AADRA1DNR3C1PTGS1 | |
| Oxalic Acid SCHEMBL5200567 | 0.77 | ADRA1A (0.38) | ADRA1AADRA2AADRA1DNR3C1PTGS1 | |
| Detomidine SCHEMBL29833001 | 0.76 | ADRA1D (0.58) | ADRA1AADRA2AADRA2CADRA2BADRA1D | |
| Detomidine SCHEMBL2626815 | 0.76 | ADRA1D (0.58) | ADRA1AADRA2AADRA2CADRA2BADRA1D | |
| Detomidine SCHEMBL29371271 | 0.75 | ADRA1D (0.59) | ADRA1AADRA2AADRA2CADRA2BADRA1D | |
| SCHEMBL5239494 | 0.74 | KEAP1 (0.47) | KEAP1NFE2L2NR3C1PTGS1ALDH1A1 | |
| SCHEMBL5203578 | 0.74 | ADRA1A (0.53) | ADRA1AADRA2AADRA2CHRH3MAPT | |
| SCHEMBL13869170 | 0.74 | KEAP1 (0.65) | KEAP1NFE2L2NR3C1PTGS1ALDH1A1 | |
| Detomidine SCHEMBL21624995 | 0.74 | ADRA1D (0.55) | ADRA1AADRA2AADRA2CADRA2BADRA1D | |
| SCHEMBL23939825 | 0.73 | ADRA1D (0.51) | ADRA1AADRA2AADRA2CADRA2BADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0887346-B1 | N-Phenyl-alkylsulfonamide derivatives, their preparation and their use as alpha1A/1L adrenoceptor agonists | HOFFMANN LA ROCHE (CH) | 2007-12-12 | — | — | EP | disclosed |
| US-6057349-A | ALPHA.SUB.1A/1L AGONISTS USED IN THE TREATMENT OF VARIOUS DISEASE STATES SUCH AS URINARY INCONTINENCE, NASAL CONGESTION, PRIAPISM, DEPRESSION, ANXIETY, DEMENTIA, SENILITY, ALZHEIMER'S, DEFICIENCIES IN ATTENTIVENESS AND COGNITION, AND | F. HOFFMAN LA ROCHE AG (CH) | 2000-05-02 | — | — | US | disclosed |
| EP-0887346-A2 | Phenyl-and aminophenyl-alkylsulfonamide and urea derivatives, their preparation and their use as alpha1A/1L adrenoceptor agonists | F. HOFFMANN-LA ROCHE AG (CH) | 1998-12-30 | — | — | EP | disclosed |