Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 2/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21636133 | 0.77 | HRH3 (0.57) | HRH3MAPTHRH4TAAR1CYP3A4 | |
| SCHEMBL5206471 | 0.75 | ADRA2A (0.54) | ADRA1AADRA2AHRH3MAPTHRH4 | |
| SCHEMBL5201429 | 0.74 | ADRA1A (0.48) | ADRA1AADRA2AHRH3MAPTHRH4 | |
| SCHEMBL5204050 | 0.74 | ADRA1A (0.42) | ADRA1AADRA2AHRH3MAPTHRH4 | |
| SCHEMBL7099288 | 0.74 | MAPT (0.43) | ADRA1AADRA2AMAPTADRA2CSMN1; SMN2 | |
| SCHEMBL12299574 | 0.73 | MAPT (0.67) | ADRA1AADRA2AMAPTADRA2CSMN1; SMN2 | |
| SCHEMBL5200888 | 0.71 | RAD52 (0.49) | ADRA1AADRA2ATAAR1ADRA2C | |
| SCHEMBL27551589 | 0.71 | HRH3 (0.53) | HRH3MAPTHRH4TAAR1CYP3A4 | |
| Hydrochloric Acid SCHEMBL5201249 | 0.70 | RAD52 (0.48) | ADRA1AADRA2AMAPTTAAR1ADRA2C | |
| Oxalic Acid SCHEMBL5200567 | 0.70 | ADRA1A (0.38) | ADRA1AADRA2AHRH3MAPTHRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0887346-B1 | N-Phenyl-alkylsulfonamide derivatives, their preparation and their use as alpha1A/1L adrenoceptor agonists | HOFFMANN LA ROCHE (CH) | 2007-12-12 | — | — | EP | disclosed |
| US-6057349-A | ALPHA.SUB.1A/1L AGONISTS USED IN THE TREATMENT OF VARIOUS DISEASE STATES SUCH AS URINARY INCONTINENCE, NASAL CONGESTION, PRIAPISM, DEPRESSION, ANXIETY, DEMENTIA, SENILITY, ALZHEIMER'S, DEFICIENCIES IN ATTENTIVENESS AND COGNITION, AND | F. HOFFMAN LA ROCHE AG (CH) | 2000-05-02 | — | — | US | disclosed |
| US-5973038-A | Thermoplastic polymer compositions containing black dye compositions | EASTMAN CHEMICAL COMPANY (US) | 1999-10-26 | — | — | US | disclosed |
| US-5952362-A | INHIBITOR OF GLYCOGEN PHOSPHORYLASE ENZYMETIC ACTIVITY AND GLUCOSE ACITIVITY | SYNTEX (U.S.A) INC. (US) | 1999-09-14 | — | — | US | disclosed |
| EP-0887346-A2 | Phenyl-and aminophenyl-alkylsulfonamide and urea derivatives, their preparation and their use as alpha1A/1L adrenoceptor agonists | F. HOFFMANN-LA ROCHE AG (CH) | 1998-12-30 | — | — | EP | disclosed |