Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CPB2 | Q96IY4 | 5/20 | 0.40 |
| ▸ | CPB1 | P15086 | 2/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.39 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL17398081 | 0.98 | NPC1 (0.43) | NPC1RAB9ANLRP3CYP3A4CPB2 | |
| SCHEMBL25199075 | 0.81 | LMNA (0.38) | NPC1RAB9ANLRP3CYP3A4CYP2E1 | |
| SCHEMBL17632468 | 0.79 | LMNA (0.38) | NPC1RAB9ANLRP3CYP3A4FLT3 | |
| SCHEMBL25215032 | 0.79 | MAP4K4 (0.49) | NPC1RAB9ANLRP3PI4KAPI4K2B | |
| SCHEMBL25212633 | 0.79 | ENPP2 (0.46) | NPC1RAB9ANLRP3CYP3A4FGFR1 | |
| SCHEMBL17632340 | 0.79 | CYP2A6 (0.65) | CYP3A4CYP2E1CYP2A6PI4KAPI4K2B | |
| SCHEMBL30513257 | 0.79 | CYP2A6 (0.65) | CYP3A4CYP2E1CYP2A6PI4KAPI4K2B | |
| Hydrochloric Acid SCHEMBL25219950 | 0.78 | LMNA (0.37) | NPC1RAB9ANLRP3CYP3A4FLT3 | |
| SCHEMBL31095252 | 0.77 | PI4KA (0.47) | PI4KAPI4K2BPI4K2API4KBMAPT | |
| SCHEMBL25202979 | 0.77 | PI4KA (0.47) | PI4KAPI4K2BPI4K2API4KBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 58 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7238212-B2 | Imidazole compounds and use of these compounds for dyeing keratinous fibers | L'OREAL, S.A. (FR) | 2007-07-03 | — | — | US | claimed |
| US-20050011019-A1 | Novel imidazole compounds and use of these compounds for dyeing keratinous fibers | L'OREAL, S.A. (FR) | 2005-01-20 | — | — | US | claimed |
| EP-1484049-A1 | Imidazole compounds and their use for dyeing of keratinous fibres | L'OREAL (FR) | 2004-12-08 | — | — | EP | claimed |
| CN-119060060-A | Imidazole-containing ALK2 kinase inhibitors | 拜奥克里斯特制药公司 | 2024-12-03 | — | — | CN | disclosed |
| CN-112823151-B | Compounds and compositions for the treatment of diseases associated with STING activity | 艾福姆德尤股份有限公司 | 2024-11-15 | — | — | CN | disclosed |
| US-20240376117-A1 | IMIDAZOLE-CONTAINING INHIBITORS OF ALK2 KINASE | WILMINGTON TRUST, NATIONAL ASSOCIATION | 2024-11-14 | — | — | US | disclosed |
| CN-110913855-B | Imidazole-containing ALK2 kinase inhibitors | 拜奥克里斯特制药公司 | 2024-09-03 | — | — | CN | disclosed |
| US-12054492-B2 | Imidazole-containing inhibitors of ALK2 kinase | BIOCRYST PHARMACEUTICALS, INC. (US) | 2024-08-06 | — | — | US | disclosed |
| US-11993595-B2 | Compounds | MISSION THERAPEUTICS LIMITED (GB) | 2024-05-28 | — | — | US | disclosed |
| US-20230271975-A1 | IMIDAZOLE-CONTAINING INHIBITORS OF ALK2 KINASE | WILMINGTON TRUST, NATIONAL ASSOCIATION | 2023-08-31 | — | — | US | disclosed |
| US-20230271975-A1 | IMIDAZOLE-CONTAINING INHIBITORS OF ALK2 KINASE | WILMINGTON TRUST, NATIONAL ASSOCIATION | 2023-08-31 | — | — | US | disclosed |
| WO-2018065768-A1 | CYANO-SUBSTITUTED HETEROCYCLES WITH ACTIVITY AS INHIBITORS OF USP30 | MISSION THERAPEUTICS LIMITED (GB) | 2018-04-12 | — | — | WO | disclosed |
| US-9926307-B2 | Compounds | MISSION THERAPEUTICS LTD (GB) | 2018-03-27 | — | — | US | disclosed |
| WO-2017158381-A1 | 4,6 DIHYDROPYRROLO [3,4-C] PYRAZOLE-5 (1H)-CARBONITRILE DERIVATES FOR TRATING CANCER | MISSION THERAPEUTICS LIMITED (GB) | 2017-09-21 | — | — | WO | disclosed |
| US-20170247365-A1 | NOVEL COMPOUNDS | MISSION THERAPEUTICS LTD (GB) | 2017-08-31 | — | — | US | disclosed |
| CN-107001339-A | Novel compounds | 特殊治疗有限公司 | 2017-08-01 | — | — | CN | disclosed |
| WO-2017109488-A1 | CYANOPYRROLIDINE DERVIVATIVES AS INHIBITORS FOR DUBS | MISSION THERAPEUTICS LIMITED (GB) | 2017-06-29 | — | — | WO | disclosed |
| US-7238212-B2 | Imidazole compounds and use of these compounds for dyeing keratinous fibers | L'OREAL, S.A. (FR) | 2007-07-03 | — | — | US | disclosed |
| US-20050011019-A1 | Novel imidazole compounds and use of these compounds for dyeing keratinous fibers | L'OREAL, S.A. (FR) | 2005-01-20 | — | — | US | disclosed |
| EP-1484049-A1 | Imidazole compounds and their use for dyeing of keratinous fibres | L'OREAL (FR) | 2004-12-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230271975-A1 | IMIDAZOLE-CONTAINING INHIBITORS OF ALK2 KINASE | ALK, ACVR2B, ACVR2A | NPC1 1978/4885RAB9A 2837/4885NLRP3 1851/4885 |
| US-11993595-B2 | Compounds | UCHL1, UCHL3, UCHL5 | NPC1 2436/4885RAB9A 519/4885NLRP3 3313/4885 |
| US-20240376117-A1 | IMIDAZOLE-CONTAINING INHIBITORS OF ALK2 KINASE | ALK, ACVR2B, ACVR2A | NPC1 1978/4885RAB9A 2837/4885NLRP3 1851/4885 |
| US-12054492-B2 | Imidazole-containing inhibitors of ALK2 kinase | ALK, ACVR2B, ACVR2A | NPC1 1978/4885RAB9A 2837/4885NLRP3 1851/4885 |
| US-20170247365-A1 | NOVEL COMPOUNDS | UCHL1, UCHL3, UCHL5 | NPC1 2546/4885RAB9A 480/4885NLRP3 3383/4885 |
| US-20050011019-A1 | Novel imidazole compounds and use of these compounds for dyeing keratinous fibers | KRT18, VIM, NDUFS6 | NPC1 4789/4885RAB9A 3755/4885NLRP3 3242/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.