Trifluoroacetic Acid

Trifluoroacetic Acid

SCHEMBL5201682

NCc1cccc(Oc2ccccc2N(Cc2ccc(Oc3ccccc3)cc2)C(=O)CCC(=O)NCc2ccccn2)c1.O=C(O)C(F)(F)F

nearest known ligand 0.41

Full drug profile on Sugi Atlas →

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.40
KMT2A Q03164 2/20 0.40
MAPK14 Q16539 1/20 0.40
HPGD P15428 1/20 0.40
ALOX15 P16050 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
CACNA1H O95180 1/20 0.38
CACNA1B Q00975 1/20 0.38
POLB P06746 1/20 0.37
MEN1 O00255 1/20 0.37
MAPK1 P28482 1/20 0.37
LOX P28300 1/20 0.37
LOXL2 Q9Y4K0 1/20 0.37
NR3C1 P04150 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoroacetic Acid SCHEMBL5205467 0.92 SCN9A (0.39) ALDH1A1KMT2AHPGDALOX15TDP1
Trifluoroacetic Acid SCHEMBL5207958 0.90 SMN1; SMN2 (0.47) ALDH1A1KMT2AHPGDTDP1POLB
Trifluoroacetic Acid SCHEMBL5207856 0.89 KMT2A (0.37) ALDH1A1KMT2AHPGDALOX15TDP1
Trifluoroacetic Acid SCHEMBL5202054 0.88 TSPO (0.39) NR3C1
Trifluoroacetic Acid SCHEMBL5207332 0.88 TPSAB1 (0.44) ALDH1A1KMT2AMEN1MAPK1LOX
Trifluoroacetic Acid SCHEMBL5203155 0.87 LPAR1 (0.38) ALDH1A1MAPK14CACNA1HCACNA1BPOLB
Trifluoroacetic Acid SCHEMBL5205760 0.87 ALDH1A1 (0.39) ALDH1A1CACNA1HCACNA1BPOLBNR3C1
Trifluoroacetic Acid SCHEMBL5206005 0.87 TSPO (0.47) ALDH1A1KMT2AHPGDMEN1NR3C1
Trifluoroacetic Acid SCHEMBL5205240 0.87 MAPK14 (0.39) ALDH1A1MAPK14TDP1CACNA1HCACNA1B
Trifluoroacetic Acid SCHEMBL5208616 0.86 TSPO (0.38) KMT2AMAPK14CACNA1HCACNA1BMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7160887-B1 Aromatic amine derivatives, their production and use TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-01-09 US disclosed
EP-1123918-B1 AROMATIC AMINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND AGENTS CONTAINING THE SAME TAKEDA PHARMACEUTICAL (JP) 2005-03-09 EP disclosed
EP-1123918-A1 AROMATIC AMINE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND AGENTS CONTAINING THE SAME Takeda Chemical Industries, Ltd. (JP) 2001-08-16 EP disclosed